T
Timothy R. Orchard
Researcher at Imperial College Healthcare
Publications - 12
Citations - 3043
Timothy R. Orchard is an academic researcher from Imperial College Healthcare. The author has contributed to research in topics: Crohn's disease & Infliximab. The author has an hindex of 9, co-authored 12 publications receiving 2217 citations. Previous affiliations of Timothy R. Orchard include Imperial College London & St Mary's Hospital.
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Journal ArticleDOI
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Jimmy Z. Liu,S van Sommeren,Hailiang Huang,Siew C. Ng,Rudi Alberts,Atsushi Takahashi,Stephan Ripke,James Lee,Luke Jostins,Tejas Shah,Shifteh Abedian,Jae Hee Cheon,Judy H. Cho,N E Dayani,Lude Franke,Yuta Fuyuno,Ailsa L. Hart,Ramesh C. Juyal,Garima Juyal,Won Ho Kim,Andrew P. Morris,Hossein Poustchi,William G. Newman,Vandana Midha,Timothy R. Orchard,H Vahedi,Ajit Sood,J Y Sung,Reza Malekzadeh,Westra H-J.,Keiko Yamazaki,Yang S-K.,Jeffrey C. Barrett,Behrooz Z. Alizadeh,Miles Parkes,T Bk,Mark J. Daly,Michiaki Kubo,Carl A. Anderson,Rinse K. Weersma +39 more
TL;DR: The first trans-ancestry association study of IBD is reported, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and immunochip data from 9,846 individuals of East Asian, Indian or Iranian descent, implicate 38 loci in IBD risk for the first time.
Journal ArticleDOI
The First European Evidence-Based Consensus on Extra-Intestinal Manifestations in Inflammatory Bowel Disease
Marcus Harbord,Vito Annese,Stephan R. Vavricka,Matthieu Allez,Manuel Barreiro-de Acosta,Kirsten Muri Boberg,Johan Burisch,Martine De Vos,Annemarie C. de Vries,Andrew D. Dick,Pascal Juillerat,Tom H. Karlsen,Ioannis E. Koutroubakis,Peter L. Lakatos,Timothy R. Orchard,Pavol Papay,Tim Raine,Max Reinshagen,Diamant Thaci,Herbert Tilg,Franck Carbonnel +20 more
TL;DR: This is the first European Crohn’s and Colitis Organisation [ECCO] consensus guideline that addresses extra-intestinal manifestations in inflammatory bowel disease [IBD] and represents consensus with agreement of at least 80% of participants.
Journal ArticleDOI
Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study
Nicholas A. Kennedy,Nicholas A. Kennedy,Nicholas A. Kennedy,Graham A. Heap,Harry D Green,Benjamin Hamilton,Claire Bewshea,Gareth J. Walker,Amanda Thomas,Rachel Nice,Mandy H Perry,Sonia Bouri,Neil Chanchlani,Neel Heerasing,Peter Hendy,Simeng Lin,Daniel R. Gaya,J R Fraser Cummings,J R Fraser Cummings,Christian P. Selinger,Charlie W. Lees,Charlie W. Lees,Ailsa L. Hart,Miles Parkes,Shaji Sebastian,John C Mansfield,Peter M. Irving,James O. Lindsay,Richard K Russell,Timothy J. McDonald,Dermot P.B. McGovern,James R Goodhand,James R Goodhand,Tariq Ahmad,Tariq Ahmad,Vinod B. Patel,Zia Mazhar,Rebecca Saich,Ben Colleypriest,Tony C.K. Tham,Tariq Iqbal,Vishal Kaushik,Senthil V. Murugesan,Salil Singh,Sean Weaver,Cathryn Preston,Assad Butt,Melissa A. Smith,Dharamveer Basude,Amanda Beale,Sarah Langlands,Natalie C. Direkze,Franco Torrente,Juan De La Revella Negro,Christopher Macdonald,Stephen M. Evans,Anton V J Gunasekera,Alka Thakur,David A Elphick,Achuth Shenoy,Chuka U. Nwokolo,Anjan Dhar,Andrew T. Cole,Anurag Agrawal,Stephen Bridger,Julie Doherty,Sheldon C. Cooper,Shanika de Silva,Craig Mowat,Phillip Mayhead,Charlie W. Lees,Gareth R. Jones,James W Hart,Lisa Gervais,Paul Dunckley,Tariq Mahmood,Paul R. Banim,Sunil Sonwalkar,Deb Ghosh,Rosemary H Phillips,Amer Azaz,Richard Shenderey,Lawrence Armstrong,Claire Bell,Radhakrishnan Hariraj,Helen Matthews,Hasnain Jafferbhoy,Veena Zamvar,John de Caestecker,Anne Willmott,Richard A. Miller,Palani Sathish Babu,Christos Tzivinikos,Stuart Bloom,Guy Chung-Faye,Nicholas M. Croft,John Fell,Marcus Harbord,Ailsa Hart,Ben Hope,James O Lindsay,Joel Mawdsley,Alistair McNair,Kevin J. Monahan,Charles Murray,Timothy R. Orchard,Thankam Paul,Richard Pollok,Neil Shah,Matthew W. Johnson,Anita Modi,Kasamu Dawa Kabiru,B K Baburajan,Bim Bhaduri,Andrew A. Fagbemi,Scott Levison,Jimmy K. Limdi,Gill Watts,Stephen Foley,Arvind Ramadas,George MacFaul,John C. Mansfield,Leonie Grellier,Mary-Anne Morris,Mark Tremelling,Christopher J. Hawkey,Sian Kirkham,Charles Pj Charlton,Astor Rodrigues,Alison Simmons,Stephen Lewis,Jonathon Snook,Mark Tighe,Patrick Goggin,Aminda De Silva,Simon Lal,Mark S. Smith,Simon Panter,Suranga Dharmisari,M J Carter,David Watts,Zahid Mahmood,Bruce McLain,Sandip Sen,Anna J Pigott,David Hobday,Emma Wesley,R B Johnston,Cathryn Edwards,John Beckly,Deven Vani,Subramaniam Ramakrishnan,Rakesh Chaudhary,Nigel Trudgill,Rachel Cooney,Andrew Bell,Neeraj Prasad,John N. Gordon,Matthew J Brookes,Andy Li,Stephen Gore +160 more
TL;DR: Clinical and pharmacokinetic factors that predict primary non-response at week 14 after starting treatment, non-remission at week 54, and adverse events leading to drug withdrawal are identified.
Journal ArticleDOI
HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants
Graham A. Heap,Michael N. Weedon,Claire Bewshea,Abhey Singh,Mian Chen,Jack B Satchwell,Julian P. Vivian,Kenji So,Patrick Dubois,Jane M. Andrews,Vito Annese,Peter A. Bampton,Martin Barnardo,Sally Bell,Andy Cole,Susan J. Connor,Tom Creed,Fraser Cummings,Mauro D'Amato,Tawfique K. Daneshmend,Richard N. Fedorak,Timothy H. Florin,Daniel R. Gaya,Emma Greig,Jonas Halfvarson,Alisa Hart,Peter M. Irving,Gareth R. Jones,Amir Karban,Ian C. Lawrance,James Lee,Charlie W. Lees,Raffi Lev-Tzion,James O. Lindsay,John C. Mansfield,Joel Mawdsley,Zia Mazhar,Miles Parkes,Kirstie Parnell,Timothy R. Orchard,Graham L. Radford-Smith,Richard K. Russell,David Reffitt,Jack Satsangi,Mark S. Silverberg,Giacomo Carlo Sturniolo,Mark Tremelling,Epameinondas V. Tsianos,David A. van Heel,Alissa Walsh,Gill Watermeyer,Rinse K. Weersma,Sebastian Zeissig,Jamie Rossjohn,Arthur L. Holden,Tariq Ahmad +55 more
TL;DR: Strong evidence of association within the class II HLA region is identified within the HLA-DQA1*02:01–HLA-DRB1*07:01 haplotype, with the most significant association identified at rs2647087, with a 9% risk of developing pancreatitis after administration of a thiopurine.
Journal ArticleDOI
Analysis of Exhaled Breath Volatile Organic Compounds in Inflammatory Bowel Disease: A Pilot Study
Lucy C. Hicks,Juzheng Huang,Sacheen Kumar,Sam T. Powles,Timothy R. Orchard,George B. Hanna,Horace R T Williams +6 more
TL;DR: Exhaled breath VOC profiling was able to distinguish IBD patients from controls, as well as to separate UC from CD, using both multivariate and univariate statistical techniques.