J
Jae Hung Shieh
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 10
Citations - 798
Jae Hung Shieh is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 6, co-authored 10 publications receiving 774 citations.
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Journal ArticleDOI
Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells.
Koichi Hattori,Beate Heissig,Kei Tashiro,Tasuku Honjo,Masatoshi Tateno,Jae Hung Shieh,Neil R. Hackett,Mannix S. Quitoriano,Ronald G. Crystal,Shahin Rafii,Malcolm A.S. Moore +10 more
TL;DR: It is demonstrated that overexpression of SDF1 in the peripheral circulation results in the mobilization of hematopoietic cells with repopulating capacity, progenitor cells, and precursor cells.
Journal ArticleDOI
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells
Kimberly A. Hartwell,Kimberly A. Hartwell,Kimberly A. Hartwell,Peter Miller,Peter Miller,Siddhartha Mukherjee,Alissa R. Kahn,Alison L. Stewart,David J. Logan,Joseph Negri,Mildred Duvet,Mildred Duvet,Marcus Järås,Rishi V. Puram,Rishi V. Puram,Vlado Dančík,Fatima Al-Shahrour,Fatima Al-Shahrour,Thomas Kindler,Zuzana Tothova,Zuzana Tothova,Shrikanta Chattopadhyay,Shrikanta Chattopadhyay,Thomas P. Hasaka,Rajiv Narayan,Mingji Dai,Mingji Dai,Christina Huang,Sebastian Shterental,Lisa P. Chu,J. Erika Haydu,Jae Hung Shieh,David P. Steensma,Benito Munoz,Joshua A. Bittker,Alykhan F. Shamji,Paul A. Clemons,Nicola Tolliday,Anne E. Carpenter,D. Gary Gilliland,Andrew M. Stern,Malcolm A.S. Moore,David T. Scadden,David T. Scadden,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber,Benjamin L. Ebert,Todd R. Golub +48 more
TL;DR: The cholesterol-lowering drug lovastatin showed anti-LSC activity in vitro and in an in vivo bone marrow transplantation model, and Mechanistic studies demonstrated that the effect was on target, via inhibition of HMG-CoA reductase.
Journal ArticleDOI
Cyclin C Regulates Human Hematopoietic Stem/Progenitor Cell Quiescence
Yasuhiko Miyata,Yasuhiko Miyata,Yan Liu,Vladimir Jankovic,Goro Sashida,Jennifer May Lee,Jae Hung Shieh,Tomoki Naoe,Malcolm A.S. Moore,Stephen D. Nimer +9 more
TL;DR: These studies establish cyclin C as a critical regulator of the G0/G1 transition of human HSPCs and suggest that modulating Cyclin C levels may be useful for HSC expansion and more efficient engraftment.
Journal ArticleDOI
The Paf oncogene is essential for hematopoietic stem cell function and development
Yacine M. Amrani,Jonathan Gill,Armine Matevossian,Eric S. Alonzo,Chingwen Yang,Jae Hung Shieh,Malcolm A.S. Moore,Christopher Y. Park,Derek B. Sant'Angelo,Lisa K. Denzin +9 more
TL;DR: The Paf oncogene is highly expressed in cycling hematopoietic stem cells (HSCs) and is required for the development of long-term HSCs.
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Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand.
P. Feugier,Deog Yeon Jo,Jae Hung Shieh,Karen L. MacKenzie,Shahin Rafii,Ronald G. Crystal,Malcolm A.S. Moore +6 more
TL;DR: It is demonstrated that continuous generation of high levels of TPO, FL, and KL as well as other factors secreted by endothelium provided a clinically relevant co-culture method for ex vivo expansion of stem and progenitor cells from cryopreserved CD34(+) populations.