J
J. Erika Haydu
Researcher at Broad Institute
Publications - 4
Citations - 553
J. Erika Haydu is an academic researcher from Broad Institute. The author has contributed to research in topics: Haematopoiesis & Progenitor cell. The author has an hindex of 4, co-authored 4 publications receiving 475 citations. Previous affiliations of J. Erika Haydu include Brigham and Women's Hospital.
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Journal ArticleDOI
Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells
Ann Mullally,Steven W. Lane,Steven W. Lane,Brian Ball,Christine Megerdichian,Rachel Okabe,Fatima Al-Shahrour,Fatima Al-Shahrour,Mahnaz Paktinat,J. Erika Haydu,Elizabeth Housman,Allegra M. Lord,Gerlinde Wernig,Michael G. Kharas,Thomas Mercher,Jeffery L. Kutok,D. Gary Gilliland,D. Gary Gilliland,Benjamin L. Ebert,Benjamin L. Ebert,Benjamin L. Ebert +20 more
TL;DR: In insights into the consequences of JAK2 activation on HSC differentiation and function, the MPN is serially transplantable and it is demonstrated that the HSC compartment has the unique capacity for disease initiation but does not have a significant selective competitive advantage over wild-type HSCs.
Journal ArticleDOI
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells
Kimberly A. Hartwell,Kimberly A. Hartwell,Kimberly A. Hartwell,Peter Miller,Peter Miller,Siddhartha Mukherjee,Alissa R. Kahn,Alison L. Stewart,David J. Logan,Joseph Negri,Mildred Duvet,Mildred Duvet,Marcus Järås,Rishi V. Puram,Rishi V. Puram,Vlado Dančík,Fatima Al-Shahrour,Fatima Al-Shahrour,Thomas Kindler,Zuzana Tothova,Zuzana Tothova,Shrikanta Chattopadhyay,Shrikanta Chattopadhyay,Thomas P. Hasaka,Rajiv Narayan,Mingji Dai,Mingji Dai,Christina Huang,Sebastian Shterental,Lisa P. Chu,J. Erika Haydu,Jae Hung Shieh,David P. Steensma,Benito Munoz,Joshua A. Bittker,Alykhan F. Shamji,Paul A. Clemons,Nicola Tolliday,Anne E. Carpenter,D. Gary Gilliland,Andrew M. Stern,Malcolm A.S. Moore,David T. Scadden,David T. Scadden,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber,Benjamin L. Ebert,Todd R. Golub +48 more
TL;DR: The cholesterol-lowering drug lovastatin showed anti-LSC activity in vitro and in an in vivo bone marrow transplantation model, and Mechanistic studies demonstrated that the effect was on target, via inhibition of HMG-CoA reductase.
Journal ArticleDOI
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to γ-secretase inhibitors
Thomas Kindler,Melanie G. Cornejo,Claudia Scholl,Jianing Liu,Dena S. Leeman,J. Erika Haydu,Stefan Fröhling,Benjamin H. Lee,D. Gary Gilliland,D. Gary Gilliland +9 more
TL;DR: Patients with T-cell leukemia with K-Ras mutations may benefit from therapies that target the NOTCH pathway alone or in combination with inhibition of the PI3K/AKT/MTOR and RAS/MAPK pathways.
Journal ArticleDOI
Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML
Zuzana Tothova,Zuzana Tothova,Anne-Laure Valton,Rebecca A. Gorelov,Mounica Vallurupalli,Mounica Vallurupalli,John M. Krill-Burger,Amie Holmes,Catherine C. Landers,J. Erika Haydu,Edyta Malolepsza,Christina R. Hartigan,Melanie Donahue,Katerina D. Popova,Sebastian Koochaki,Sergey V. Venev,Jeanne F Rivera,Edwin Chen,Kasper Lage,Monica Schenone,Alan D. D'Andrea,Steven A. Carr,Elizabeth A. Morgan,Job Dekker,Job Dekker,Benjamin L. Ebert,Benjamin L. Ebert,Benjamin L. Ebert +27 more
TL;DR: In this paper, the cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation, and DNA damage repair and replication are identified as genetic dependencies in cohesIN-mutant cells.