J
Jaime Imitola
Researcher at University of Connecticut
Publications - 101
Citations - 10178
Jaime Imitola is an academic researcher from University of Connecticut. The author has contributed to research in topics: Neural stem cell & Multiple sclerosis. The author has an hindex of 39, co-authored 94 publications receiving 9167 citations. Previous affiliations of Jaime Imitola include Ohio State University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis
Pia Kivisäkk,Jaime Imitola,Stine Rasmussen,Wassim Elyaman,Bing Zhu,Richard M. Ransohoff,Samia J. Khoury +6 more
TL;DR: It is hypothesized that activated CD4+ T cells gain direct access to the subarachnoid space and become reactivated on encounter with cognate antigen in this compartment.
Journal ArticleDOI
Persistent inflammation alters the function of the endogenous brain stem cell compartment.
Stefano Pluchino,Luca Muzio,Jaime Imitola,Michela Deleidi,Clara Alfaro-Cervello,Giuliana Salani,Cristina Porcheri,Elena Brambilla,Francesca Cavasinni,Andrea Bergamaschi,José Manuel García-Verdugo,Giancarlo Comi,Samia J. Khoury,Gianvito Martino +13 more
TL;DR: It is shown that persistent brain inflammation, induced by immune cells targeting myelin, extensively alters the proliferative and migratory properties of subventricular zone (SVZ)-resident NPCs in vivo leading to significant accumulation of non-migratory neuroblasts within the SVZ germinal niche.
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Cytokines in multiple sclerosis: from bench to bedside.
TL;DR: The current knowledge on the role of cytokine pathways in MS and what the authors learned from investigation of its animal model: experimental autoimmune encephalomyelitis (EAE) are summarized.
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Elevated neuronal expression of CD200 protects Wlds mice from inflammation-mediated neurodegeneration.
Tanuja Chitnis,Jaime Imitola,Yue Wang,Wassim Elyaman,Prianka Chawla,Maia Sharuk,Khadir Raddassi,Roderick T. Bronson,Samia J. Khoury +8 more
TL;DR: It is shown that attenuated disease in Wld(s) mice was associated with robust constitutive expression of the nonsignaling CD200 molecule on neurons in the CNS compared with control mice, and the CD200-CD200R pathway plays a critical role in attenuating EAE and reducing inflammation-mediated damage in the central nervous system.
Journal ArticleDOI
Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing--remitting experimental autoimmune encephalomyelitis.
Stine Rasmussen,Yue Wang,Pia Kivisäkk,Roderick T. Bronson,Morten Meyer,Jaime Imitola,Samia J. Khoury +6 more
TL;DR: Cortical pathology, periventricular subcortical lesions and callosal demyelination in relapsing-remitting experimental autoimmune encephalomyelitis in SJL mice that are similar to lesions found in MS are described.