J
James A. Frank
Researcher at University of California, San Francisco
Publications - 60
Citations - 4035
James A. Frank is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lung injury & Lung. The author has an hindex of 30, co-authored 59 publications receiving 3679 citations. Previous affiliations of James A. Frank include Cardiovascular Institute Hospital & University of California, Berkeley.
Papers
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Journal ArticleDOI
Allogeneic human mesenchymal stem cells for treatment of E. Coli endotoxin-induced acute lung injury in an ex vivo perfused human lung
TL;DR: In this paper, the authors tested the therapeutic capacity of human MSCs to restore alveolar epithelial fluid transport and lung fluid balance from acute lung injury (ALI) in an ex vivo perfused human lung preparation injured by E. coli endotoxin.
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Low Tidal Volume Reduces Epithelial and Endothelial Injury in Acid-injured Rat Lungs
James A. Frank,Jorge A. Gutierrez,Kirk D. Jones,Lennell Allen,Leland G. Dobbs,Michael A. Matthay +5 more
TL;DR: It is concluded that low tidal volume ventilation protects both the alveolar epithelium and the endothelium in this model of acute lung injury.
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Interleukin-1β Causes Acute Lung Injury via αvβ5 and αvβ6 Integrin–Dependent Mechanisms
Michael T. Ganter,Jérémie Roux,Byron Miyazawa,Marybeth Howard,James A. Frank,George Su,Dean Sheppard,Shelia M. Violette,Paul H. Weinreb,Gerald S. Horan,Michael A. Matthay,Jean-Francois Pittet,Jean-Francois Pittet +12 more
TL;DR: A critical role is demonstrated for the &agr;v&b Gr;5/&bgr;6 integrins in mediating the IL-1&b gr;–induced ALI and indicate that these integrINS could be a potentially attractive therapeutic target in ALI.
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OBSTRUCTIVE PULMONARY DISEASE: The Clinician's Perspective
TL;DR: In this article, the authors reviewed the differential diagnosis of obstructive lung disease, including lesions that may mimic COPD, as well as the tools on which the clinician relies for a proper diagnosis.
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Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury
TL;DR: It is demonstrated that injurious mechanical ventilation rapidly activates alveolar macrophages and that alveolars play an important role in the initial pathogenesis of VILI.