J
James B. Brown
Researcher at Lawrence Berkeley National Laboratory
Publications - 112
Citations - 25042
James B. Brown is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 39, co-authored 110 publications receiving 22484 citations. Previous affiliations of James B. Brown include University of California, Berkeley & University of Alberta.
Papers
More filters
Journal ArticleDOI
Complete Genome Sequence of Agrobacterium sp. Strain 33MFTa1.1, Isolated from Thlaspi arvense Roots.
Sasha A. Langley,Thomas Eng,Thomas Eng,Kenneth H. Wan,Robin A. Herbert,Robin A. Herbert,Andrew P. Klein,Yasuo Yoshikuni,Yasuo Yoshikuni,Susannah G. Tringe,Susannah G. Tringe,James B. Brown,James B. Brown,James B. Brown,Susan E. Celniker,Jenny C. Mortimer,Jenny C. Mortimer,Aindrila Mukhopadhyay,Aindrila Mukhopadhyay +18 more
TL;DR: Agrobacterium sp.
Journal ArticleDOI
Pd39-02 results of phase 1 clinical trial of high doses of seleno-l-methionine (slm) in sequential combination with axitinib in previously treated and relapsed clear cell renal carcinoma (ccrcc) patients
Yousef Zakharia,Rohan Garje,James B. Brown,Kenneth G. Nepple,Andrew M. Bellizzi,Jaime Bonner,Deborah Parr,Janelle B Born,Jessica C. Sieren,Jinha Park,Mohammad Milhem,Youcef M. Rustum +11 more
TL;DR: The overexpression of hypoxia induced factor 1a/2a in ccRCC leads to up-regulation of vascular endothelial growth factor (VEGF) that results in increased angiogenesis.
Posted Content
Spatial Graph Attention and Curiosity-driven Policy for Antiviral Drug Discovery
Yulun Wu,Nicholas Choma,Andrew D. Chen,Mikaela Cashman,Erica T. Prates,Manesh Shah,Verónica G Melesse Vergara,Austin Clyde,Thomas Brettin,Wibe A. de Jong,Neeraj Kumar,Martha S Head,Rick Stevens,Peter Nugent,Daniel Jacobson,James B. Brown +15 more
TL;DR: Wu et al. as discussed by the authors proposed a spatial graph attention network (sGAT) that leverages self-attention over both node and edge attributes as well as encoding spatial structure.
Posted ContentDOI
Molecular and functional characterization of the Drosophila melanogaster conserved smORFome
Justin A. Bosch,Nathan Keith,Felipe Escobedo,William F. Fisher,James Thai LaGraff,Jorden Rabasco,Kenneth H. Wan,Richard Weiszmann,Yan Mengand Qiao-Mu Hu,Shu Kondo,James B. Brown,Norbert Perrimon,Susan E. Celniker +12 more
TL;DR: This study conducted an embryonic ribosome profiling experiment and applied a machine learning approach, finding support for translation of 82 of these smORFs during embryogenesis, and embarked on functional characterization using CRISPR knockout/activation, RNAi knockdown, and cDNA overexpression, revealing diverse phenotypes.
Posted Content
BLOCCS: Block Sparse Canonical Correlation Analysis With Application To Interpretable Omics Integration.
TL;DR: This work introduces Block Sparse Canonical Correlation Analysis which estimates multiple pairs of canonical directions at once at once, resulting in significantly improved orthogonality of the sparse directions which, it is demonstrated, translates to more interpretable solutions.