J
James B. Brown
Researcher at Lawrence Berkeley National Laboratory
Publications - 112
Citations - 25042
James B. Brown is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 39, co-authored 110 publications receiving 22484 citations. Previous affiliations of James B. Brown include University of California, Berkeley & University of Alberta.
Papers
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Journal ArticleDOI
iRF: extracting interactions from random forests
TL;DR: This work presents a meta-analyses of the determinants of infectious disease in eight types of inflammatory bowel disease and shows clear patterns in response to antibiotics and in particular the immune response to E.coli.
Journal ArticleDOI
Test evaluation trials present different challenges for trial managers compared to intervention trials
Caroline Rick,Susan Mallett,James B. Brown,Ryan S Ottridge,Andrew Palmer,Victoria A. Parker,Lee Priest,Jonathan J Deeks,Jonathan J Deeks +8 more
TL;DR: Proactive identification of potential challenges at the design and planning stages of test evaluation trials will enable strategies to improve trial design and management that may be different from standard strategies used for intervention trials.
Posted Content
Learning from learning machines: a new generation of AI technology to meet the needs of science
Luca Pion-Tonachini,Kristofer E. Bouchard,Hector Garcia Martin,Sean Peisert,W. Bradley Holtz,Anil Aswani,Dipankar Dwivedi,Haruko Wainwright,Ghanshyam Pilania,Benjamin Philip Nachman,Babetta L. Marrone,Nicola Falco,Prabhat,Daniel Arnold,Alejandro Wolf-Yadlin,Sarah Powers,Sharlee Climer,Quinn Jackson,Ty Carlson,Michael Sohn,Petrus Zwart,Neeraj Kumar,Amy C. Justice,Claire J. Tomlin,Daniel Jacobson,Gos Micklem,Georgios V. Gkoutos,Peter J. Bickel,Jean-Baptiste Cazier,Juliane Müller,Bobbie-Jo Webb-Robertson,Rick Stevens,Mark Anderson,Kenneth Kreutz-Delgado,Michael W. Mahoney,James B. Brown +35 more
TL;DR: In this article, the authors outline emerging opportunities and challenges to enhance the utility of AI for scientific discovery, and address the fundamental challenges associated with "bridging the gap" between domain-driven scientific models and data-driven AI learning machines.
Journal ArticleDOI
Enhanced neoplasia detection in chronic ulcerative colitis: the ENDCaP-C diagnostic accuracy study
Ashish Awasthi,Jamie Barbour,Andrew D Beggs,Pradeep Bhandari,Daniel Blakeway,Matthew J Brookes,James B. Brown,Matthew A. Brown,Germaine Caldwell,Samuel Clokie,Ben Colleypriest,Abby Conlin,Shanika de Silva,John de Caestecker,Jonathan J Deeks,Jonathan J Deeks,Anjan Dhar,Mark P Dilworth,Edward Fogden,Stephen Foley,Deb Ghosh,Leonie Grellier,Ailsa Hart,Syed Samiul Hoque,Marietta Iacucci,Tariq Iqbal,Tariq Iqbal,Jonathan James,Mark Jarvis,Anthoor Jayaprakash,Satish Keshav,Laura Magill,Glenn Matthews,Joel Mawdsley,Simon D. McLaughlin,Samir Mehta,Kevin J. Monahan,Dion Morton,Dion Morton,Senthil V. Murugesan,Miles Parkes,Valerie Pestinger,Chris Probert,Arvind Ramadas,Alessandro Rettino,Shaji Sebastian,Naveen Sharma,Michael J. Griffiths,Joanne D. Stockton,Venkat Subramanian,Nigel Suggett,Philippe Taniere,Julian Teare,Ajay Verma,Yvonne Wallis +54 more
TL;DR: Methylation testing for chronic ulcerative colitis patients cannot be recommended based on this study, but whether or not this test may be identifying a population at risk of future neoplasia and informing future surveillance programmes is investigated.
Journal ArticleDOI
Frontiers in RNA biology: Advances from a small fly Drosophila melanogaster
James B. Brown,Susan E. Celniker +1 more
TL;DR: This article discusses emerging frontiers in RNA biology from a historical perspective from ahistorical perspective and indicates that the field is currently undergoing yet another transformative expansion.