J
James D. Watson
Researcher at University of Auckland
Publications - 113
Citations - 4415
James D. Watson is an academic researcher from University of Auckland. The author has contributed to research in topics: Antigen & T cell. The author has an hindex of 33, co-authored 113 publications receiving 4393 citations. Previous affiliations of James D. Watson include Salk Institute for Biological Studies & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Continuous proliferation of murine antigen- specific helper t lymphocytes in culture*
TL;DR: Murine helper T cells activated to sheep or horse erythrocyte antigens in vivo have been established as continuous cell lines in culture and stable helper activity for greater than 50 wk in culture is shown.
Journal ArticleDOI
GENETIC CONTROL OF RESPONSES TO BACTERIAL LIPOPOLYSACCHARIDES IN MICE I. Evidence for a Single Gene that Influences Mitogenic and Immunogenic Respones to Lipopolysaccharides
James D. Watson,Roy Riblet +1 more
TL;DR: The defect in C3H/HeJ mice that limits mitogenic and immune responsiveness to be due to a single autosomal gene which is not linked to the H-2 histocompatibility or heavy-chain allotype loci.
Journal ArticleDOI
Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines.
TL;DR: The data have been interpreted as showing the two molecular forms of murine TCGF (pI 4.3 and 4.9) are responsible for many of the lymphokine activities described elsewhere as thymocyte mitogenic factor, nonspecific T-cell-replacing factor and killer helper factor or costimulator.
Journal Article
Effect of IL-7 on the growth of fetal thymocytes in culture.
TL;DR: The results suggest that IL-7 promotes the growth of cells that occur early in the T cell lineage, similar to that which normally develops in unsupplemented fetal thymus organ cultures during a 7-day period.
Journal ArticleDOI
Molecular Characterization of Interleukin 2
Steven Gillis,Steven Gillis,Steven Gillis,Diane Y. Mochizuki,Diane Y. Mochizuki,Diane Y. Mochizuki,Paul J. Conlon,Paul J. Conlon,Paul J. Conlon,Steven H. Hefeneider,Carol A. Ramthun,Carol A. Ramthun,Carol A. Ramthun,Anne E. Gillis,Anne E. Gillis,Anne E. Gillis,Mark Barton frank,Mark Barton frank,Mark Barton frank,Christopher S. Henney,Christopher S. Henney,Christopher S. Henney,James D. Watson,James D. Watson,James D. Watson +24 more
TL;DR: The isolation of specific T cell growth factors termed interleukin 2 (IL 2) is changing the approach to understanding T cell function and has allowed the establishment of a number of human and murine T cell lines.