J
James D. Young
Researcher at University of Alberta
Publications - 241
Citations - 16156
James D. Young is an academic researcher from University of Alberta. The author has contributed to research in topics: Nucleoside & Nucleoside transporter. The author has an hindex of 63, co-authored 240 publications receiving 15574 citations. Previous affiliations of James D. Young include Cornell University & Cross Cancer Institute.
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Journal ArticleDOI
Improved Syntheses of 5′-S-(2-Aminoethyl)-6-N-(4-nitrobenzyl)-5′-thioadenosine (SAENTA), Analogues, and Fluorescent Probe Conjugates: Analysis of Cell-Surface Human Equilibrative Nucleoside Transporter 1 (hENT1) Levels for Prediction of the Antitumor Efficacy of Gemcitabine
Morris J. Robins,Yunshan Peng,Vijaya L. Damaraju,Delores Mowles,Geraldine Barron,Tracey Tackaberry,James D. Young,Carol E. Cass +7 more
TL;DR: Fluorescent probes that bound at nanomolar concentrations specifically to human equilibrative nucleoside transporter 1 (hENT1) were produced in recombinant form in model expression systems and in native form in cancer cell lines.
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The Role of Human Nucleoside Transporters in Cellular Uptake of 4′-Thio-β-d-arabinofuranosylcytosine and β-d-Arabinosylcytosine
Marilyn L Clarke,Vijaya L. Damaraju,Jing Zhang,Delores Mowles,Tracey Tackaberry,Thach Lang,Kyla M. Smith,James D. Young,Blake Tomkinson,Carol E. Cass +9 more
TL;DR: During prolonged drug exposures of CEM cells with hENT1 activity, araC was more cytotoxic than TaraC, whereas coexposures with nitrobenzylthioinosine (to pharmacologically block hENT4′-Thio-β-d-arabinofuranosyl cytosine) yielded identical cytot toxicities for aRAC and TaraC.
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Identification and functional characterization of variants in human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene.
Sambasivarao Damaraju,Jing Zhang,Frank Visser,Tracey Tackaberry,Jennifer Dufour,Kyla M. Smith,Melissa D. Slugoski,Mabel W.L. Ritzel,Stephen A. Baldwin,James D. Young,Carol E. Cass +10 more
TL;DR: A high degree of conservation of function for hCNT3 in the Caucasian population is suggested based on measurements of radioisotope flux and two-electrode voltage-clamp studies.
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Human Nucleoside Transporters: Biomarkers for Response to Nucleoside Drugs
TL;DR: HNT abundance, evaluated by immunohistochemical methods, has shown promise as a predictive marker to assess clinical drug response that could be used to identify patients who would most likely benefit from nucleoside analog drug treatment.
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Identification of the nucleoside transporter in cultured mouse lymphoma cells. Photoaffinity labeling of plasma membrane-enriched fractions from nucleoside transport-competent (S49) and nucleoside transport-deficient (AE1) cells with [3H]nitrobenzylthioinosine.
TL;DR: Plasma membrane-enriched fractions from disrupted S49 lymphoma cells contained high affinity sites for [3H]nitrobenzylthioinosine, a potent and specific inhibitor of nucleoside transport, which resulted in covalent radiolabeling of a membrane protein which migrated on sodium dodecyl sulfate-polyacrylamide gels.