J
James D. Young
Researcher at University of Alberta
Publications - 241
Citations - 16156
James D. Young is an academic researcher from University of Alberta. The author has contributed to research in topics: Nucleoside & Nucleoside transporter. The author has an hindex of 63, co-authored 240 publications receiving 15574 citations. Previous affiliations of James D. Young include Cornell University & Cross Cancer Institute.
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Journal ArticleDOI
Sodium-dependent cysteine transport in human red blood cells
TL;DR: It is reported here that human RBCs transport L-cysteine by a previously unidentified high affinity, low capacity, Na- dependent uptake mechanism, which has a uniquely high affinity for its substrate and is the first Na-dependent transport mechanism to be kinetically characterised in mammalian erythrocytes.
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Heterogeneity of amino acid transport in horse erythrocytes: a detailed kinetic analysis of inherited transport variation.
TL;DR: The effects of low temperature on system asc2 suggest a preferential impairment of the mobility of the unloaded carrier relative to that of the loaded transporter, and the different kinetic properties of systems asc1 and asc2 at physiological temperature are attributed to a difference in the mobilities of the empty carriers.
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Insulin binding and effects on pyrimidine nucleoside uptake and incorporation in cultured mouse astrocytes.
TL;DR: It is confirmed that mouse astrocytes in vitro possess specific insulin receptors and an effect of insulin on pyrimidine nucleoside uptake and incorporation is demonstrated.
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Parasite-induced processes for adenosine permeation in mouse erythrocytes infected with the malarial parasite Plasmodium yoelii.
TL;DR: In mouse erythrocytes harbouring the malarial parasite Plasmodium yoelii, three processes contributed to inward fluxes of adenosine, one of which is attributed to the native nucleoside transporter, because of the inhibitory effects of nitrobenzylthioinosine (NBMPR).
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Differential expression of human equilibrative nucleoside transporter 1 (hENT1) protein in the Reed-Sternberg cells of Hodgkin's disease.
Tony Reiman,Marilyn L Clarke,Laith Dabbagh,Michaela Vsianska,Robert W. Coupland,Andrew R. Belch,Stephen A. Baldwin,James D. Young,Carol E. Cass,John R. Mackey +9 more
TL;DR: Immunohistochemical staining for hENT1 warrants evaluation as a predictive tool for guiding the appropriate use of gemcitabine in the treatment of HD.