J
James D. Young
Researcher at University of Alberta
Publications - 241
Citations - 16156
James D. Young is an academic researcher from University of Alberta. The author has contributed to research in topics: Nucleoside & Nucleoside transporter. The author has an hindex of 63, co-authored 240 publications receiving 15574 citations. Previous affiliations of James D. Young include Cornell University & Cross Cancer Institute.
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Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins
TL;DR: The best-characterized members of the human SLC29 family of integral membrane proteins, hENT1 and hent2, possess similar broad permeant selectivities for purine and pyrimidine nucleosides, but hENT2 also efficiently transports nucleobases, while hENT3 and hENT4 are pH sensitive, and optimally active under acidic conditions.
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Functional and Molecular Characterization of Nucleobase Transport by Recombinant Human and Rat Equilibrative Nucleoside Transporters 1 and 2 CHIMERIC CONSTRUCTS REVEAL A ROLE FOR THE ENT2 HELIX 5–6 REGION IN NUCLEOBASE TRANSLOCATION
Sylvia Y.M. Yao,Amy M. L. Ng,Mark F. Vickers,Manickavasagam Sundaram,Carol E. Cass,Stephen A. Baldwin,James D. Young +6 more
TL;DR: Hypoxanthine transport experiments provide the first direct demonstration that the ENT2 isoform is a dual mechanism for the cellular uptake of nucleosides and nucleobases, both of which are physiologically important salvage metabolites.
Journal ArticleDOI
Nucleoside transport and its significance for anticancer drug resistance
TL;DR: Recent advances in the molecular biology of nucleoside transport proteins are summarized, the current state of knowledge of the transportability of therapeutically useful anticancer nucleosides is reviewed, and several strategies for utilization of nucleOSide transport processes to improve the therapeutic index of anticancer therapies are presented.
Journal ArticleDOI
Molecular biology of nucleoside transporters and their distributions and functions in the brain.
Fiona E. Parkinson,Vijaya L. Damaraju,Kathryn Graham,Sylvia Y.M. Yao,Stephen A. Baldwin,Carol E. Cass,James D. Young +6 more
TL;DR: Current knowledge of cellular, physiological, pathophysiological and therapeutic aspects of ENT and CNT distribution and function in the mammalian brain are reviewed, including studies with NT inhibitors and new research involving NT knockout and transgenic mice are described.