J
James Laredo
Researcher at University of Maryland, Baltimore
Publications - 9
Citations - 930
James Laredo is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Adrenal cortex & Ouabain. The author has an hindex of 9, co-authored 9 publications receiving 909 citations.
Papers
More filters
Journal ArticleDOI
In Vivo Molecular Imaging of Acute and Subacute Thrombosis Using a Fibrin-Binding Magnetic Resonance Imaging Contrast Agent
René M. Botnar,Alexandra S. Perez,Sonia Witte,Andrea J. Wiethoff,James Laredo,James A. Hamilton,William C. Quist,Edward C. Parsons,Anand Vaidya,Andrew Kolodziej,John A. Barrett,Philip B. Graham,Robert M. Weisskoff,Warren J. Manning,Michael T. Johnstone +14 more
TL;DR: The feasibility of in vivo “molecular” MRI for the detection of acute and subacute thrombosis using a novel fibrin-binding MRI contrast agent in an animal model of atherosclerosis and acute/subacuteThROMbosis is demonstrated.
Journal ArticleDOI
Ouabain is secreted by bovine adrenocortical cells.
TL;DR: Results show that ouabain is enriched in the bovine adrenal cortex, and is secreted by primary cultures of these cells, which may be useful to study stimulus-secretion coupling and the biosynthetic pathway of ou abain.
Journal ArticleDOI
Angiotensin II Stimulates Secretion of Endogenous Ouabain From Bovine Adrenocortical Cells via Angiotensin Type 2 Receptors
TL;DR: The results demonstrate that AT2 receptors stimulate secretion of endogenous ouabain from bovine adrenocortical cells and indicates that separate signaling mechanisms having minimal cross talk control the adrenoc Cortical secretions of corticosteroids and cardiac-active steroids.
Journal ArticleDOI
Observations on the Nature, Biosynthesis, Secretion and Significance of Endogenous Ouabain
John M. Hamlyn,Zhuo Ren Lu,Paolo Manunta,James H. Ludens,Keizo Kimura,Jui R. Shah,James Laredo,James P. Hamilton,Matthew J. Hamilton,Bruce P. Hamilton +9 more
TL;DR: It is suggested that at least one of the mammalian counterparts to the cardiac glycosides is a novel steroidal isomer of ouabain, which is secreted by the adrenal cortex, and augments cardiovascular function.
Journal ArticleDOI
Secretion of endogenous ouabain from bovine adrenocortical cells: role of the zona glomerulosa and zona fasciculata.
TL;DR: Findings suggest that endogenous ouabain is primarily synthesized and secreted from the adrenal zona glomerulosa, and not from the bovine adrenal cortex.