J
James M. Musser
Researcher at Houston Methodist Hospital
Publications - 477
Citations - 44674
James M. Musser is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Streptococcus pyogenes & Virulence. The author has an hindex of 113, co-authored 461 publications receiving 42030 citations. Previous affiliations of James M. Musser include Rocky Mountain Laboratories & Baylor College of Medicine.
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Journal ArticleDOI
Comparison of Methods Based on Different Molecular Epidemiological Markers for Typing of Mycobacterium tuberculosis Complex Strains: Interlaboratory Study of Discriminatory Power and Reproducibility
Kristin Kremer,D. van Soolingen,Richard Frothingham,Walter H. Haas,Peter W. M. Hermans,Carlos Martin,Prasit Palittapongarnpim,Bonnie B. Plikaytis,Lee W. Riley,Mitchell A. Yakrus,James M. Musser,J. D. A. Van Embden +11 more
TL;DR: Strain differentiation by IS6110 RFLP or mixed-linker PCR are the methods of choice for epidemiological investigations, indicating a clonal population structure of M. tuberculosis strains.
Journal ArticleDOI
Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-α/β
Claudia Manca,Liana Tsenova,Amy Bergtold,Sherry Freeman,Michael G. Tovey,James M. Musser,Clifton E. Barry,Victoria H. Freedman,Gilla Kaplan +8 more
TL;DR: The results suggest that the hypervirulence of HN878 may be due to failure of this strain to stimulate Th1 type immunity, and the lack of development of Th1 immunity in response to Hn878 appears to be associated with increased induction of Type 1 IFNs.
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Genome sequence of a serotype M3 strain of group A Streptococcus: Phage-encoded toxins, the high-virulence phenotype, and clone emergence
Stephen B. Beres,Gail L. Sylva,Kent D. Barbian,Benfang Lei,Jessica S. Hoff,Nicole D. Mammarella,Meng Yao Liu,James C. Smoot,Stephen F. Porcella,Larye D. Parkins,David S. Campbell,Todd M. Smith,John K. McCormick,Donald Leung,Patrick M. Schlievert,James M. Musser +15 more
TL;DR: The results show that phage-mediated recombination has played a critical role in the emergence of a new, unusually virulent clone of serotype M3 GAS.
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spa Typing Method for Discriminating among Staphylococcus aureus Isolates: Implications for Use of A Single Marker to Detect Genetic Micro- and Macrovariation
Larry Koreen,Srinivas V. Ramaswamy,Edward A. Graviss,Steven Naidich,James M. Musser,James M. Musser,Barry N. Kreiswirth +6 more
TL;DR: It is determined that S. aureus likely has a primarily clonal population structure and that spa typing can singly index genetic variation with 88% direct concordance with the microarray and can correctly assign isolates to phylogenetic lineages.
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Evolutionary Genomics of Staphylococcus Aureus: Insights Into the Origin of Methicillin-Resistant Strains and the Toxic Shock Syndrome Epidemic
TL;DR: It is found that lateral gene transfer has played a fundamental role in the evolution of S. aureus, demonstrating that methicillin-resistant strains have evolved multiple independent times, rather than from a single ancestral strain.