J
James R. Van Brocklyn
Researcher at Ohio State University
Publications - 45
Citations - 5549
James R. Van Brocklyn is an academic researcher from Ohio State University. The author has contributed to research in topics: Receptor & Sphingosine-1-phosphate. The author has an hindex of 32, co-authored 45 publications receiving 5357 citations. Previous affiliations of James R. Van Brocklyn include Max Delbrück Center for Molecular Medicine & University of Connecticut Health Center.
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Journal ArticleDOI
Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1
Menq Jer Lee,James R. Van Brocklyn,James R. Van Brocklyn,James R. Van Brocklyn,Shobha Thangada,Shobha Thangada,Shobha Thangada,Catherine H. Liu,Catherine H. Liu,Catherine H. Liu,Arthur R. Hand,Arthur R. Hand,Arthur R. Hand,Ramil Menzeleev,Ramil Menzeleev,Ramil Menzeleev,Sarah Spiegel,Sarah Spiegel,Sarah Spiegel,Timothy Hla,Timothy Hla,Timothy Hla +21 more
TL;DR: Overexpression of EDG-1 induced exaggerated cell-cell aggregation, enhanced expression of cadherins, and formation of well-developed adherens junctions in a manner dependent on SPP and the small guanine nucleotide binding protein Rho.
Journal ArticleDOI
Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival
James R. Van Brocklyn,Menq Jer Lee,Ramil Menzeleev,Ana Olivera,Lisa C. Edsall,Olivier Cuvillier,Dianne M. Thomas,Peter Coopman,Shobha Thangada,Catherine H. Liu,Timothy Hla,Sarah Spiegel +11 more
TL;DR: Sphingosine-1-phosphate is a prototype for a novel class of lipid mediators that act both extracellularly as ligands for cell surface receptors and intracellulary as second messengers.
Journal ArticleDOI
MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells.
Jakub Godlewski,Michał Nowicki,Agnieszka Bronisz,Gerard J. Nuovo,Jeff Palatini,Michael De Lay,James R. Van Brocklyn,Michael C. Ostrowski,E. Antonio Chiocca,Sean E. Lawler +9 more
TL;DR: Overexpression of miR-451 sensitized cells to glucose deprivation, suggesting that its downregulation is necessary for robust activation of LKB1 in response to metabolic stress, and this may represent a fundamental mechanism that contributes to cellular adaptation in Response to altered energy availability.
Journal ArticleDOI
Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor POTENTIAL INVOLVEMENT IN ANGIOGENESIS
Fang Wang,James R. Van Brocklyn,John P. Hobson,Sharareh Movafagh,Zofia Zukowska-Grojec,Sheldon Milstien,Sarah Spiegel +6 more
TL;DR: The results suggest that SPP may play a role in angiogenesis through binding to endothelial cell Gi-coupled SPP receptors and checkerboard analysis indicated that sphingosine 1-phosphate stimulates both chemotaxis and chemokinesis.
Journal ArticleDOI
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines.
James R. Van Brocklyn,Catherine A Jackson,Dennis K. Pearl,Mark S. Kotur,Pamela J. Snyder,Thomas W. Prior +5 more
TL;DR: Surprisingly, RNA interference to knockdown SphK2 expression inhibited glioblastoma cell proliferation more potently than did SphK1 knockdown, and SphK knockdown prevented cells from exiting G1 phase of the cell cycle and marginally increased apoptosis.