James Trevor Oswald

TL;DR: It is shown that PTEN messenger RNA can be reintroduced into PTEN-null prostate cancer cells in vitro and in vivo via its encapsulation in polymer–lipid hybrid nanoparticles coated with a polyethylene glycol shell and this work provides proof-of-principle evidence of the restoration of mRNA-based tumour suppression in vivo.

TL;DR: TPGS modified nanoliposomes were a promising ocular delivery carriers for Brz to treat glaucoma and might be worthy of further translational study.

TL;DR: The results indicated that iRGD modified liposomes could prolong the corneal retention time and enhance Corneal permeability in an iR GD receptor mediated manner and provided a novel strategy for topical ocular drug delivery for the treatment of posterior ocular diseases.

TL;DR: Drug delivery systems used for platinum and combinational therapeutic delivery are introduced, and progress in leveraging the cytotoxic nature of platinum based drugs, the combinational effect of other drugs with platinum are highlighted, while evaluating the drug targeting, side effect reducing and site-specific nature of nanotechnology based delivery platforms.

TL;DR: A biomimetic octopus-like structure integrating merits of multiarm and multivalent interaction is designed for ultraspecific capture and detection of pathogens.