T
Thomas Earnest
Researcher at Lawrence Berkeley National Laboratory
Publications - 51
Citations - 6044
Thomas Earnest is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Beamline & Transfer RNA. The author has an hindex of 25, co-authored 50 publications receiving 5830 citations. Previous affiliations of Thomas Earnest include Boston University & Chinese Academy of Sciences.
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Journal ArticleDOI
Crystal structure of the ribosome at 5.5 A resolution
Marat Yusupov,Gulnara Yusupova,Albion E. Baucom,Kate R. Lieberman,Thomas Earnest,Jamie H. D. Cate,Harry F. Noller +6 more
TL;DR: The crystal structure of the complete Thermus thermophilus 70S ribosome containing bound messenger RNA and transfer RNAs (tRNAs) at 5.5 angstrom resolution is described, suggesting coupling of the 20 to 50 angstrom movements associated with tRNA translocation with intersubunit movement.
Journal ArticleDOI
X-ray Crystal Structures of 70S Ribosome Functional Complexes
TL;DR: Structures of 70S ribosome complexes containing messenger RNA and transfer RNA (tRNA), or tRNA analogs, have been solved by x-ray crystallography at up to 7.8 angstrom resolution.
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From words to literature in structural proteomics
TL;DR: The goal is a comprehensive description of the multitude of interactions between molecular entities, which is a prerequisite for the discovery of general structural principles that underlie all cellular processes.
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A Polymeric Protein Anchors the Chromosomal Origin/ParB Complex at a Bacterial Cell Pole
Grant R. Bowman,Luis R. Comolli,Jian Zhu,Michael Eckart,Marcelle Koenig,Kenneth H. Downing,W. E. Moerner,Thomas Earnest,Lucy Shapiro +8 more
TL;DR: This work has identified a proline-rich polar protein, PopZ, required to anchor the separated Caulobacter crescentus chromosome origins at the cell poles, a function that is essential for maintaining chromosome organization and normal cell division.
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Extending X-Ray Crystallography to Allow the Imaging of Noncrystalline Materials, Cells, and Single Protein Complexes
TL;DR: The principles of the X-ray crystallography methodology are reviewed, recent developments in each of the three directions are summarized, and a few examples are illustrated.