J
Jan A. Burger
Researcher at University of Texas MD Anderson Cancer Center
Publications - 543
Citations - 33028
Jan A. Burger is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Chronic lymphocytic leukemia & Ibrutinib. The author has an hindex of 83, co-authored 511 publications receiving 28306 citations. Previous affiliations of Jan A. Burger include University of Texas Health Science Center at Houston & University of Freiburg.
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Journal ArticleDOI
Phosphorylated CXCR4 is associated with poor survival in adults with B-acute lymphoblastic leukemia.
Sergej Konoplev,Jeffrey L. Jorgensen,Deborah A. Thomas,E. Lin,Jan A. Burger,Hagop M. Kantarjian,Michael Andreeff,L. Jeffrey Medeiros,Marina Konopleva +8 more
Abstract: BACKGROUND:
CXC chemokine receptor 4 (CXCR4) is activated by phosphorylation (pCXCR4) and is essential for the migration of hematopoietic precursors to bone marrow. CXCR4 overexpression predicts a poor prognosis in patients with acute myeloid leukemia. Data regarding the prognostic impact of CXCR4 in patients with B-acute lymphoblastic leukemia (B-ALL) are sparse and limited to the pediatric population.
METHODS:
The authors analyzed CXCR4 and pCXCR4 expression in 54 adults with newly diagnosed B-ALL. CXCR4 was assessed by flow cytometry (FC) and immunohistochemistry (IHC) using an anti-CXCR4 antibody. pCXCR4 expression was assessed using an anti-pCXCR4 antibody.
RESULTS:
The study group included 30 men and 24 women with a median age of 42 years (range, 17-84 years). Philadelphia chromosome was present in 19 patients. The median follow-up was 16 months (range, 17-84 months). Forty-nine patients had a complete response, and 12 patients relapsed with a median relapse free survival >120 weeks. Fifteen patients (28%) died with a median survival >125 weeks. CXCR4 detected by FC and IHC was highly correlated (P < .001). CXCR4 was not associated with clinical or laboratory findings or survival. In contrast, pCXCR4 was associated with higher leukocyte count (P = .006) and serum bilirubin level (P = .03). In multivariate analysis, pCXCR4 expression (P = .027), high serum creatinine level (P < .01), presence of the Philadelphia chromosome (P = .017), and late clinical response (P < .001) were associated with worse overall survival.
CONCLUSIONS:
The current results indicated that detection of the activated form of CXCR4, pCXCR4, provides independent prognostic information in adult patients with B-ALL. Cancer 2011;. © 2011 American Cancer Society.
Journal ArticleDOI
Updated Efficacy and Safety from the Phase 3 Resonate-2 Study: Ibrutinib As First-Line Treatment Option in Patients 65 Years and Older with Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia
Paul M. Barr,Tadeusz Robak,Carolyn Owen,Alessandra Tedeschi,Osnat Bairey,Nancy L. Bartlett,Jan A. Burger,Peter Hillmen,Steven Coutre,Stephen Devereux,Sebastian Grosicki,Helen McCarthy,Jianyong Li,David Simpson,Fritz Offner,Carol Moreno,Cathy Zhou,Lori Styles,Danelle F. James,Thomas J. Kipps,Paolo Ghia +20 more
TL;DR: Ibrutinib (ibr), a first-in-class, once-daily, inhibitor of Bruton9s tyrosine kinase, is indicated by the US FDA for the treatment of pts with CLL/SLL and allows for treatment without chemotherapy.
Journal ArticleDOI
The combination of hyper-CVAD plus nelarabine as frontline therapy in adult T-cell acute lymphoblastic leukemia and T-lymphoblastic lymphoma: MD Anderson Cancer Center experience.
Punit Jain,Hagop M. Kantarjian,Farhad Ravandi,Deborah A. Thomas,Stephen J. O'Brien,Tapan M. Kadia,Jan A. Burger,G. Borthakur,Naval Daver,E. Jabbour,Marina Konopleva,J. E. Cortes,Naveen Pemmaraju,Mary A. Kelly,Marylou Cardenas-Turanzas,Rebecca E. Garris,Stephan Faderl +16 more
TL;DR: The combination of hyper-CVAD plus nelarabine as frontline therapy in adult T-cell acute lymphoblastic leukemia and T-lymphoblastic lymphoma: MD Anderson Cancer Center experience.
Journal ArticleDOI
Buparlisib, a PI3K inhibitor, demonstrates acceptable tolerability and preliminary activity in a phase I trial of patients with advanced leukemias
Brittany Knick Ragon,Hagop M. Kantarjian,Elias Jabbour,Farhad Ravandi,Jorge E. Cortes,Gautam Borthakur,La Kiesha Debose,Zhihong Zeng,Heather Schneider,Naveen Pemmaraju,Guillermo Garcia-Manero,Steven M. Kornblau,William G. Wierda,Jan A. Burger,Courtney D. DiNardo,Michael Andreeff,Marina Konopleva,Naval Daver +17 more
TL;DR: BKM120 administered at 80 mg/day showed modest efficacy and was tolerable in advanced acute leukemias and the most frequent drug‐related toxicities included confusion, mucositis, dysphagia, and fatigue.
Journal ArticleDOI
Efficacy of nilotinib (AMN107) in patients (Pts) with newly diagnosed, previously untreated philadelphia chromosome (Ph)- positive chronic myelogenous leukemia in early chronic phase (CML-CP)
J. E. Cortes,Susan O'Brien,A. Ferrajoli,G. Borthakur,Jan A. Burger,William G. Wierda,G. Garcia-Manero,Laurie Letvak,Hagop M. Kantarjian +8 more
TL;DR: A phase II study to evaluate the efficacy of nilotinib as 1st line therapy in pts with newly diagnosed CML-CP found that the rate of complete cytogenetic response at 3, 6 and 12 mo compares favorably to those observed in historical controls treated with imatinib 400mg or 800 mg daily.