J
Jan O. Aasly
Researcher at Norwegian University of Science and Technology
Publications - 193
Citations - 16161
Jan O. Aasly is an academic researcher from Norwegian University of Science and Technology. The author has contributed to research in topics: Parkinson's disease & LRRK2. The author has an hindex of 53, co-authored 175 publications receiving 14369 citations. Previous affiliations of Jan O. Aasly include University of British Columbia.
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NMR spectroscopy study of the effect of 3-nitropropionic acid on glutamate metabolism in cultured astrocytes
Inger Johanne Bakken,Inger Johanne Bakken,Svein F. Johnsen,Svein F. Johnsen,Linda R. White,Geirmund Unsgård,Jan O. Aasly,Ursula Sonnewald +7 more
TL;DR: The present results show that astrocyte metabolism is more adaptable to blockade of the tricarboxylic acid cycle by 3‐NPA than neuronal metabolism.
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Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2
Mareike Caesar,Sandra Felk,Susanne Zach,Gunnar Bronstad,Jan O. Aasly,Thomas Gasser,Frank Gillardon +6 more
TL;DR: It is shown that PGRN levels are significantly reduced in conditioned medium of LRRK2(R1441G) mutant mouse fibroblasts, leukocytes, and microglia, whereas levels of proinflammatory factors, like interleukin‐1β and keratinocyte‐derived chemokine, were significantly increased.
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Altered expression of PGK1 in a family with phosphoglycerate kinase deficiency.
TL;DR: This study characterized the PGK1 gene in a family of two brothers, two sisters, and their parents and indicated that inhibition of the transcription mechanism is the cause of PGK deficiency.
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Amino acid neurotransmitter metabolism in neurones and glia following kainate injection in rats
TL;DR: It is suggested that increased neuronal activity 2 weeks following epileptic seizures produces increased amino acid turnover in neurones and changes in astrocytic metabolism were not detected.
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Genealogical studies in LRRK2-associated Parkinson's disease in central Norway.
TL;DR: The study provides support for a common ancestor in Norwegian families with LRRK2 p.G2019S parkinsonism and the extended pedigree that now links modern day carriers may help in mapping penetrance modifiers.