J
Jan O. Aasly
Researcher at Norwegian University of Science and Technology
Publications - 193
Citations - 16161
Jan O. Aasly is an academic researcher from Norwegian University of Science and Technology. The author has contributed to research in topics: Parkinson's disease & LRRK2. The author has an hindex of 53, co-authored 175 publications receiving 14369 citations. Previous affiliations of Jan O. Aasly include University of British Columbia.
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Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants.
Michael G. Heckman,Alexis Elbaz,Owen A. Ross,Matthew J. Farrer,Demetrius M. Maraganore,Georgia Xiromerisiou,Ruey-Meei Wu,Zbigniew K. Wszolek,Karin Wirdefeldt,Linda R. White,Carles Vilariño Güell,Demetrios K. Vassilatis,Enza Maria Valente,Ryan J. Uitti,Hiroyuki Tomiyama,Vera Tadic,Leonidas Stefanis,Young H. Sohn,Peter A. Silburn,Manu Sharma,Aldo Quattrone,Simona Petrucci,Sung Sup Park,Grzegorz Opala,Eugénie Mutez,George D. Mellick,Timothy Lynch,Marie-Anne Loriot,Katja Lohmann,Chin-Hsien Lin,Elli Kyratzi,Rejko Krüger,Christine Klein,Yun Joong Kim,Beom S. Jeon,Barbara Jasinska Myga,John P. A. Ioannidis,Nobutaka Hattori,Georgios M. Hadjigeorgiou,Suzana Gispert,Brian K. Fiske,Alessandro Ferraris,Carlo Ferrarese,Alain Destée,Efthimios Dardiotis,Marie Christine Chartier Harlin,Laura Brighina,Maria Bozi,Magdalena Boczarska Jedynak,Justin A. Bacon,Georg Auburger,Grazia Annesi,Jan O. Aasly,Daniel J. Serie,Alexandra I. Ortolaza +54 more
TL;DR: The results indicate that the association of LRRK2 p.R1398H with Parkinson's disease is independent of SNCA and MAPT variants, and vice versa, in Caucasian and Asian populations.
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Glial-neuronal interactions following kainate injection in rats.
TL;DR: It can be suggested that increased astrocytic activity 1 day after epileptic seizures results, subsequently, in an increased amino acid turnover in neurons.
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Cheek cell-derived α-synuclein and DJ-1 do not differentiate Parkinson's disease from control.
Tessandra Stewart,Yu Ting Sui,Luis F. Gonzalez-Cuyar,David T.W. Wong,David Akin,Vitor Tumas,Jan O. Aasly,Emily Ashmore,Patrick Aro,Carmen Ginghina,Ane Korff,Cyrus P. Zabetian,Cyrus P. Zabetian,James B. Leverenz,James B. Leverenz,Min Shi,Jing Zhang +16 more
TL;DR: Cheek epithelium was identified, which forms the majority of the cellular component of saliva and is readily accessible clinically, as 1 of several potential sources of salivary α-syn and DJ-1, but no PD-related trend was present.
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Fine-mapping and candidate gene investigation within the PARK10 locus.
Kristoffer Haugarvoll,Kristoffer Haugarvoll,Mathias Toft,Lisa Skipper,Michael G. Heckman,Julia E. Crook,Alexandra I. Soto,Owen A. Ross,Mary M. Hulihan,Jennifer M. Kachergus,Sigrid Botne Sando,Linda R. White,Timothy Lynch,Timothy Lynch,J. Mark Gibson,Ryan J. Uitti,Zbigniew K. Wszolek,Jan O. Aasly,Matthew J. Farrer +18 more
TL;DR: The data indicate that genetic variability in USP24 is associated with PD, and the observed effect size does not explain the PARK10 linkage peak.
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ELAVL4, PARK10, and the Celts.
Kristoffer Haugarvoll,Kristoffer Haugarvoll,Mathias Toft,Mathias Toft,Owen A. Ross,Jeremy T. Stone,Michael G. Heckman,Linda R. White,Timothy Lynch,John Mark Gibson,Zbigniew K. Wszolek,Ryan J. Uitti,Jan O. Aasly,Matthew J. Farrer +13 more
TL;DR: The data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic‐founder effect, and two markers were significantly associated with susceptibility to PD in the authors' Irish series.