J
Jan O. Aasly
Researcher at Norwegian University of Science and Technology
Publications - 193
Citations - 16161
Jan O. Aasly is an academic researcher from Norwegian University of Science and Technology. The author has contributed to research in topics: Parkinson's disease & LRRK2. The author has an hindex of 53, co-authored 175 publications receiving 14369 citations. Previous affiliations of Jan O. Aasly include University of British Columbia.
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Journal ArticleDOI
Manganese, copper, and zinc in cerebrospinal fluid from patients with multiple sclerosis
Torun M Melø,Cecilie Larsen,Linda R. White,Jan O. Aasly,Torill Eidhammer Sjøbakk,Trond Peder Flaten,Ursula Sonnewald,Tore Syversen +7 more
TL;DR: The physiological basis for the differences inManganese and copper concentrations between MS patients and controls is unknown, but could be related to alterations in the manganese- containing enzyme glutamine synthetase and the copper-containing enzyme cytochrome oxidase.
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Higher frequency of certain cancers in LRRK2 G2019S mutation carriers with Parkinson disease: a pooled analysis.
Ilir Agalliu,Marta San Luciano,Anat Mirelman,Nir Giladi,Nir Giladi,Bjorg Waro,Jan O. Aasly,Rivka Inzelberg,Rivka Inzelberg,Sharon Hassin-Baer,Sharon Hassin-Baer,Eitan Friedman,Eitan Friedman,J. Ruiz-Martinez,Jose Felix Marti-Masso,Avi Orr-Urtreger,Avi Orr-Urtreger,Susan B. Bressman,Susan B. Bressman,Susan B. Bressman,Rachel Saunders-Pullman,Rachel Saunders-Pullman,Rachel Saunders-Pullman +22 more
TL;DR: This multinational study from 5 centers demonstrates that LRRK2 G2019S mutation carriers have an overall increased risk of cancer, especially for hormone-related cancer and breast cancer in women.
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Risk-reducing effect of education in Alzheimer's disease
Sigrid Botne Sando,Stacey Melquist,Ashley Cannon,Mike Hutton,Olav Sletvold,Ingvild Saltvedt,Linda R. White,Stian Lydersen,Jan O. Aasly +8 more
TL;DR: The aim is to estimate the effect of education on the risk of Alzheimer's disease (AD) and to determine the optimal level of education for children to be at a higher risk of the disease.
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MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease
TL;DR: Signalling changes in MAPK‐signalling may be common to PD pathophysiology, regardless of aetiology, and may be particularly important for the development of neuroprotective strategies to delay onset, or slow progression of PD.
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Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS): a misdiagnosed disease entity
Christina Sundal,Jennifer Lash,Jan O. Aasly,Sarka Øygarden,Sigrun Roeber,Hans Kretzschman,James Y. Garbern,Alex Tselis,Rosa Rademakers,Dennis W. Dickson,Daniel F. Broderick,Zbigniew K. Wszolek +11 more
TL;DR: Clinical findings, genealogical data, brain MRI data, and autopsy/biopsy findings of four probands from three independently ascertained novel families from Norway, Germany and US showHDLS is an under-recognized disease and in reporting these cases, it aims to increase the awareness of the disorder.