J
Jan O. Aasly
Researcher at Norwegian University of Science and Technology
Publications - 193
Citations - 16161
Jan O. Aasly is an academic researcher from Norwegian University of Science and Technology. The author has contributed to research in topics: Parkinson's disease & LRRK2. The author has an hindex of 53, co-authored 175 publications receiving 14369 citations. Previous affiliations of Jan O. Aasly include University of British Columbia.
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Journal ArticleDOI
Cytokines increase endothelin ETB receptor contractile activity in rat cerebral artery.
TL;DR: The plasticity of ETB receptor expression in cerebral arteries and sensitivity for pro-inflammatory cytokines, suggest a role in inflammatory cerebral diseases such as stroke.
Journal ArticleDOI
Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium.
Michael G. Heckman,Alexandra I. Soto-Ortolaza,Jan O. Aasly,Nadine Abahuni,Grazia Annesi,Justin A. Bacon,Soraya Bardien,Maria Bozi,Alexis Brice,Laura Brighina,Jonathan Carr,Marie-Christine Chartier-Harlin,Efthimios Dardiotis,Dennis W. Dickson,Nancy N. Diehl,Alexis Elbaz,Carlo Ferrarese,Brian K. Fiske,J. Mark Gibson,Rachel A. Gibson,Georgios M. Hadjigeorgiou,Nobutaka Hattori,John P. A. Ioannidis,Magdalena Boczarska-Jedynak,Barbara Jasinska-Myga,Beom S. Jeon,Yun Joong Kim,Christine Klein,Rejko Krüger,Elli Kyratzi,Suzanne Lesage,Suzanne Lesage,Chin-Hsien Lin,Timothy Lynch,Demetrius M. Maraganore,George D. Mellick,Eugénie Mutez,Christer Nilsson,Grzegorz Opala,Sung Sup Park,Simona Petrucci,Andreas Puschmann,Aldo Quattrone,Manu Sharma,Peter A. Silburn,Young H. Sohn,Leonidas Stefanis,Vera Tadic,Jessie Theuns,Hiroyuki Tomiyama,Ryan J. Uitti,Enza Maria Valente,Christine Van Broeckhoven,Simone Van De Loo,Demetrios K. Vassilatis,Carles Vilariño-Güell,Linda R. White,Karin Wirdefeldt,Zbigniew K. Wszolek,Ruey-Meei Wu,Fayçal Hentati,Matthew J. Farrer,Owen A. Ross +62 more
TL;DR: Leucine‐rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late‐onset sporadic disorders like Parkinson's disease.
PINK1 mutation heterozygosity and the risk of Parkinson's
TL;DR: In this paper, mutations in PTEN-induced kinase 1 (PINK1) gene have been identified in recessively inherited and sporadic early-onset parkinsonism (EOP).
Journal ArticleDOI
Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease.
Julie P. Taylor,Mary M. Hulihan,Jennifer M. Kachergus,Heather L. Melrose,Sarah Lincoln,Kelly M. Hinkle,Jeremy T. Stone,Owen A. Ross,Robert A. Hauser,Jan O. Aasly,Thomas Gasser,Haydeh Payami,Zbigniew K. Wszolek,Matthew J. Farrer +13 more
TL;DR: Comparison of evolutionary interspecies sequences of LRRK1 and L RRK2 suggests they diverged from a common founder gene, highlighting a greater conservation of sequence than observed for LRRk2.
Journal ArticleDOI
Proton magnetic resonance spectroscopy of cerebrospinal fluid in neurodegenerative disease: indication of glial energy impairment in Huntington chorea, but not Parkinson disease.
Mari Gårseth,Ursula Sonnewald,Linda R. White,Marianne Rød,John-Anker Zwart,Ø. P. Nygaard,Jan O. Aasly +6 more
TL;DR: The reduction in lactate found in the present study may reflect neuronal loss and support the theory of mitochondrial dysfunction in the brain of patients with Huntington chorea, but also suggests that there may be an important astrocytic component in this disease.