J
Jan O. Aasly
Researcher at Norwegian University of Science and Technology
Publications - 193
Citations - 16161
Jan O. Aasly is an academic researcher from Norwegian University of Science and Technology. The author has contributed to research in topics: Parkinson's disease & LRRK2. The author has an hindex of 53, co-authored 175 publications receiving 14369 citations. Previous affiliations of Jan O. Aasly include University of British Columbia.
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Journal ArticleDOI
A Case of Parkinson's Disease with No Lewy Body Pathology due to a Homozygous Exon Deletion in Parkin.
Krisztina K. Johansen,Sverre H. Torp,Matthew J. Farrer,Emil K. Gustavsson,Emil K. Gustavsson,Jan O. Aasly +5 more
TL;DR: This case report presents a patient who developed parkinsonism around the age of 20, with an excellent response to levodopa who, at age 65, received bilateral STN deep brain stimulation (DBS).
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Cerebrospinal fluid amyloid β and tau in LRRK2 mutation carriers
Jan O. Aasly,Min Shi,Vesna Sossi,Tessandra Stewart,Krisztina K. Johansen,Zbigniew K. Wszolek,Ryan J. Uitti,Kazuko Hasegawa,T. Yokoyama,Cyrus P. Zabetian,Hojoong M. Kim,James B. Leverenz,Carmen Ginghina,Jeff Armaly,Karen L. Edwards,Katherine W. Snapinn,A. J. Stoessl,Jing Zhang +17 more
TL;DR: The disposition of Aβ and tau is likely important in both LRRK2-related and sporadic PD, even during early phases of the disease, a better understanding of their production, aggregation, and degradation may provide insights into the pathogenesis of PD and the potential utility of these proteins as biomarkers.
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PINK1 mutation heterozygosity and the risk of Parkinson’s disease
TL;DR: PINK1 mutations are rare in Norwegian patients with EOP and familial Parkinson’s disease, however, the data suggest that some heterozygous mutations might increase the risk of developing Parkinson's disease.
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SNCA, MAPT, and GSK3B in Parkinson disease: a gene–gene interaction study
Christian Wider,Christian Wider,Carles Vilariño-Güell,Michael G. Heckman,Barbara Jasinska-Myga,Barbara Jasinska-Myga,A. I. Ortolaza-Soto,Nancy N. Diehl,Julia E. Crook,Stephanie A. Cobb,Justin A. Bacon,Jan O. Aasly,J. M. Gibson,Timothy Lynch,Ryan J. Uitti,Zbigniew K. Wszolek,Matthew J. Farrer,Owen A. Ross +17 more
TL;DR: This study attempts to validate previously published findings, evaluating gene–gene interactions between SNCA, MAPT, and GSK3B in association with PD.
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Prevalence of haemochromatosis gene mutations in Parkinson’s disease
Anne Hege Aamodt,Lars Jacob Stovner,Ketil Thorstensen,Stian Lydersen,Linda R. White,Jan O. Aasly +5 more
TL;DR: Genotype frequencies of the HFE mutations C282Y, H63D and S65C were estimated in 388 patients with Parkinson’s disease and compared with frequencies found in comparable studies and no significant differences were found in frequencies between the patients and comparable populations.