G
Gregg Duester
Researcher at Discovery Institute
Publications - 173
Citations - 13765
Gregg Duester is an academic researcher from Discovery Institute. The author has contributed to research in topics: Retinoic acid & Alcohol dehydrogenase. The author has an hindex of 63, co-authored 167 publications receiving 12574 citations. Previous affiliations of Gregg Duester include University of California, Irvine & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Retinoic Acid Synthesis and Signaling during Early Organogenesis
TL;DR: Recent studies suggest that retinoic acid may act primarily in a paracrine manner and provide insight into the cell-cell signaling networks that control differentiation of pluripotent cells.
Journal ArticleDOI
Families of retinoid dehydrogenases regulating vitamin A function
TL;DR: Compilation of the known retinoid dehydrogenases indicates the existence of 17 nonorthologous forms: five ADHs, eight SDRs, and four ALDHs,Eight of which are conserved in both mouse and human, suggesting a function in androgen metabolism as well as retinoids metabolism.
Journal ArticleDOI
Mechanisms of retinoic acid signalling and its roles in organ and limb development
TL;DR: In vivo studies have identified RAREs that control repression of Fgf8 during body axis extension or activation of homeobox (Hox) genes and other key regulators during neuronal differentiation and organogenesis.
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An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment
Nianwei Lin,Kung-Yen Chang,Zhonghan Li,Keith P. Gates,Zacharia A. Rana,Jason Dang,Danhua Zhang,Tian Xu Han,Chao-Shun Yang,Thomas J. Cunningham,Steven R. Head,Gregg Duester,P. Duc Si Dong,Tariq M. Rana,Tariq M. Rana +14 more
TL;DR: It is suggested that the lincRNA TUNA plays a vital role in pluripotency and neural differentiation of ESCs and is associated with neurological function of adult vertebrates.
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Retinaldehyde represses adipogenesis and diet-induced obesity.
Ouliana Ziouzenkova,Gabriela Orasanu,Molly Sharlach,Taro E. Akiyama,Joel P. Berger,Jason Viereck,James A. Hamilton,Guangwen Tang,Gregory G. Dolnikowski,Silke Vogel,Gregg Duester,Jorge Plutzky +11 more
TL;DR: It is shown that Rald is present in rodent fat, binds retinol-binding proteins, inhibits adipogenesis and suppresses peroxisome proliferator-activated receptor-γ and RXR responses, and is identified as a distinct transcriptional regulator of the metabolic responses to a high-fat diet.