W
Wim Vermeulen
Researcher at Erasmus University Rotterdam
Publications - 195
Citations - 20592
Wim Vermeulen is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Nucleotide excision repair & DNA repair. The author has an hindex of 74, co-authored 188 publications receiving 19121 citations. Previous affiliations of Wim Vermeulen include Centre national de la recherche scientifique & Erasmus University Medical Center.
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Journal ArticleDOI
Understanding nucleotide excision repair and its roles in cancer and ageing
TL;DR: A mechanistic model is proposed that explains the complex genotype–phenotype correlations of transcription-coupled repair disorders and uncovered new aspects of DNA-damage detection by NER, how NER is regulated by extensive post-translated modifications, and the dynamic chromatin interactions that control its efficiency.
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DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor
Laurent Schaeffer,Richard Roy,Sandrine Humbert,Vincent Moncollin,Wim Vermeulen,Jan H.J. Hoeijmakers,Pierre Chambon,Jean-Marc Egly +7 more
TL;DR: Findings suggest that transcription and nucleotide excision repair may share common factors and hence may be considered to be functionally related.
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Sequential Assembly of the Nucleotide Excision Repair Factors In Vivo
Marcel Volker,Martijn J. Moné,Parimal Karmakar,Anneke van Hoffen,Wouter Schul,Wim Vermeulen,Jan H.J. Hoeijmakers,Roel van Driel,Albert A. van Zeeland,Leon H.F. Mullenders +9 more
TL;DR: XPC is identified as the earliest known NER factor in the reaction mechanism, insight is given into the order of subsequent NER components, evidence for a dual role of XPA is provided, and a concept of sequential assembly of repair proteins at the site of the damage rather than a preassembled repairosome is supported.
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ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes.
Christine Troelstra,Alain J. van Gool,Jan de Wit,Wim Vermeulen,Dirk Bootsma,Jan H.J. Hoeijmakers +5 more
TL;DR: The characterization of ERCC6, a gene involved in preferential repair in eukaryotes, corrects the repair defect of CS complementation group B (CS-B), and encodes a protein of 1493 amino acids, containing seven consecutive domains conserved between DNA and RNA helicases.
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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
Laura J. Niedernhofer,George A. Garinis,Anja Raams,Astrid S. Lalai,Andria Rasile Robinson,Esther Appeldoorn,Hanny Odijk,Roos Oostendorp,Anwaar Ahmad,Wibeke J. Van Leeuwen,Arjan F. Theil,Wim Vermeulen,Gijsbertus T. J. van der Horst,Peter Meinecke,Wim J. Kleijer,Jan Vijg,Nicolaas G. J. Jaspers,Jan H.J. Hoeijmakers +17 more
TL;DR: It is concluded that unrepaired cytotoxic DNA damage induces a highly conserved metabolic response mediated by the IGF1/insulin pathway, which re-allocates resources from growth to somatic preservation and life extension, and demonstrates that ageing and end-of-life fitness are determined both by stochastic damage and genetics.