J
Janakiraman Subramanian
Researcher at Washington University in St. Louis
Publications - 56
Citations - 3101
Janakiraman Subramanian is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 16, co-authored 42 publications receiving 2714 citations. Previous affiliations of Janakiraman Subramanian include University of Tennessee Medical Center & Mount Sinai St. Luke's and Mount Sinai Roosevelt.
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Journal ArticleDOI
Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers
Ramaswamy Govindan,Li Ding,Malachi Griffith,Janakiraman Subramanian,Nathan D. Dees,Krishna L. Kanchi,Christopher G. Maher,Robert S. Fulton,Lucinda Fulton,John W. Wallis,Ken Chen,Jason Walker,Sandra McDonald,Ron Bose,David M. Ornitz,Dong Hai Xiong,Ming You,David J. Dooling,Mark A. Watson,Elaine R. Mardis,Richard K. Wilson +20 more
TL;DR: Cell-cycle and JAK-STAT pathways are significantly altered in lung cancer, along with perturbations in 54 genes that are potentially targetable with currently available drugs, including ROS1 and ALK, as well as novel metabolic enzymes.
Journal ArticleDOI
Lung Cancer in Never Smokers: A Review
TL;DR: Interestingly, the activating mutations in the EGFR-TK inhibitors have been reported significantly more frequently in LCINS than in patients with tobacco-related NSCLC.
Journal ArticleDOI
DGIdb: mining the druggable genome
Malachi Griffith,Obi L. Griffith,Adam C. Coffman,James V. Weible,Josh F McMichael,Nicholas C. Spies,James Koval,Indraniel Das,Matthew B. Callaway,James M. Eldred,Christopher A. Miller,Janakiraman Subramanian,Ramaswamy Govindan,Runjun D. Kumar,Ron Bose,Li Ding,Jason Walker,David E. Larson,David J. Dooling,Scott M. Smith,Timothy J. Ley,Elaine R. Mardis,Richard K. Wilson +22 more
TL;DR: The Drug-Gene Interaction database (DGIdb) provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes.
Journal ArticleDOI
Distinctive characteristics of non-small cell lung cancer (NSCLC) in the young: a surveillance, epidemiology, and end results (SEER) analysis.
Janakiraman Subramanian,Daniel Morgensztern,Boone Goodgame,Maria Q. Baggstrom,Feng Gao,Jay F. Piccirillo,Ramaswamy Govindan +6 more
TL;DR: There is a greater representation of African Americans, Asians or Pacific Islanders, women, and adenocarcinoma histology in the younger cohort of patients with NSCLC compared with the older cohort.
Journal ArticleDOI
Prognostic Impact of Malignant Pleural Effusion at Presentation in Patients with Metastatic Non–Small-Cell Lung Cancer
Daniel Morgensztern,Saiama N. Waqar,Janakiraman Subramanian,Kathryn Trinkaus,Ramaswamy Govindan +4 more
TL;DR: If these data are validated, subsequent studies in patients with advanced NSCLC may consider stratification according to the MPE status, and MPE was also an independent factor for worse survival in multivariate analysis.