D
Dong Hai Xiong
Researcher at Medical College of Wisconsin
Publications - 100
Citations - 4457
Dong Hai Xiong is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Single-nucleotide polymorphism & Lung cancer. The author has an hindex of 35, co-authored 94 publications receiving 4014 citations. Previous affiliations of Dong Hai Xiong include Xi'an Jiaotong University & Creighton University Medical Center.
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Journal ArticleDOI
Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers
Ramaswamy Govindan,Li Ding,Malachi Griffith,Janakiraman Subramanian,Nathan D. Dees,Krishna L. Kanchi,Christopher G. Maher,Robert S. Fulton,Lucinda Fulton,John W. Wallis,Ken Chen,Jason Walker,Sandra McDonald,Ron Bose,David M. Ornitz,Dong Hai Xiong,Ming You,David J. Dooling,Mark A. Watson,Elaine R. Mardis,Richard K. Wilson +20 more
TL;DR: Cell-cycle and JAK-STAT pathways are significantly altered in lung cancer, along with perturbations in 54 genes that are potentially targetable with currently available drugs, including ROS1 and ALK, as well as novel metabolic enzymes.
Journal ArticleDOI
Identification of Somatic Mutations in Non-Small Cell Lung Carcinomas Using Whole-Exome Sequencing
Pengyuan Liu,Carl Morrison,Liang Wang,Dong Hai Xiong,Peter Vedell,Peng Cui,Xing Hua,Xing Hua,Feng Ding,Yan Lu,Michael A. James,John D. Ebben,Haiming Xu,Alex A. Adjei,Karen Head,Jaime Wendt Andrae,Michael Tschannen,Howard J. Jacob,Jing Pan,Qi Zhang,Francoise Van den Bergh,Haijie Xiao,Ken C. Lo,Jigar Patel,Todd Richmond,Mary Anne Watt,Thomas J. Albert,Rebecca R. Selzer,Marshall W. Anderson,Jiang Wang,Yian Wang,Sandra L. Starnes,Ping Yang,Ming You +33 more
TL;DR: Several highly mutated genes identified in the study are promising druggable targets in cancer therapy including ALK, CTNNA3, DCC, MLL3, PCDHIIX, Pik3C2B, PIK3CG and ROCK2.
Journal ArticleDOI
Genome-wide Association and Follow-Up Replication Studies Identified ADAMTS18 and TGFBR3 as Bone Mass Candidate Genes in Different Ethnic Groups
Dong Hai Xiong,Xiao-Gang Liu,Yan-Fang Guo,Li Jun Tan,Liang Wang,Bao Yong Sha,Zi Hui Tang,Feng Pan,Tie-Lin Yang,Xiang Ding Chen,Shu Feng Lei,Laura M. Yerges,Xue Zen Zhu,Victor W. Wheeler,Alan L. Patrick,C. H. Bunker,Yan Guo,Han Yan,Yu-Fang Pei,Yin Pin Zhang,Shawn Levy,Christopher J. Papasian,Peng Xiao,Y. Wang Lundberg,Robert R. Recker,Yao Zhong Liu,Yong Jun Liu,Joseph M. Zmuda,Hong-Wen Deng +28 more
TL;DR: The evidence supports that ADAMTS18 and TGFBR3 might underlie BMD determination in the major human ethnic groups.
Journal ArticleDOI
Molecular Genetic Studies of Gene Identification for Osteoporosis: A 2004 Update
Yong Jun Liu,Hui Shen,Peng Xiao,Dong Hai Xiong,Li Hua Li,Robert R. Recker,Hong-Wen Deng,Hong-Wen Deng,Hong-Wen Deng +8 more
TL;DR: This review summarizes comprehensively the most important and representative molecular genetics studies of gene identification for osteoporosis published up to the end of December 2004, intended to constitute a sequential update of a previously published review covering the available data.
Journal ArticleDOI
Genome-wide Association and Replication Studies Identified TRHR as an Important Gene for Lean Body Mass
Xiao-Gang Liu,Xiao-Gang Liu,Li Jun Tan,Shu Feng Lei,Shu Feng Lei,Yong Jun Liu,Hui Shen,Liang Wang,Liang Wang,Han Yan,Han Yan,Yan-Fang Guo,Dong Hai Xiong,Xiang Ding Chen,Feng Pan,Tie-Lin Yang,Yin Ping Zhang,Yin Ping Zhang,Yan Guo,Nelson L.S. Tang,Xue Zhen Zhu,Hong Yi Deng,Shawn Levy,Robert R. Recker,Christopher J. Papasian,Hong-Wen Deng,Hong-Wen Deng,Hong-Wen Deng +27 more
TL;DR: Results of this study support the TRHR gene as an important gene for LBM variation, together with the functional relevance of TRHR in muscle metabolism, by using Affymetrix 500K single-nucleotide polymorphism (SNP) arrays.