Jane Wright

TL;DR: This study leads to the novel hypothesis that CHTs reside on a subpopulation of synaptic vesicles in cholinergic terminals that can transit to the plasma membrane in response to neuronal activity to couple levels of choline re-uptake to the rate of ACh release.

TL;DR: It is demonstrated that CHT is an essential and regulated presynaptic component of cholinergic signaling and indicates that it warrants consideration as a candidate gene for disorders characterized byCholinergic hypofunction.

TL;DR: The discovery of CHT dysfunction underlying motor neuropathy identifies a biological basis for this group of conditions and widens the spectrum of disorders that derive from impaired NMJ transmission, forcing consideration of mutations in SLC5A7 or its functional partners in relation to unexplained motor neuronopathies.

TL;DR: The results suggest that the change from ST‐1 expression in surrounding stromal cells to its expression in the tumor cells themselves is associated with the conversion of squamous to spindle carcinomas and may play a causal role in the ability of these cells to invade and metastasize.

TL;DR: Keratinocyte expression of MMP3 promotes cellular differentiation, impeding tumor establishment during tumorigenesis, and is suggested to have a protective role in squamous cell carcinoma.