Janet Gardner-Medwin

TL;DR: In this paper, the frequency and ethnic variation of Henoch-Schonlein purpura, Kawasaki disease, and rarer vasculitides during childhood are not well characterised.

TL;DR: 7 new mutations in 13 unrelated patients with CINCA syndrome are described and mutational hotspots in CIAS1 are identified on the basis of all mutations described to date, providing evidence of genotype/phenotype correlations and a 3-dimensional model of the nucleotide-binding domain of cryopyrin suggested that this molecule is structurally and functionally similar to members of the AAA+ protein family of ATPases.

TL;DR: The data on these patients from the UK JSLE Cohort Study indicate that severe organ involvement and significant disease activity are primary characteristics in children with juvenile SLE.

TL;DR: Diffuse endothelial dysfunction, a predictor of atherosclerotic disease, is found extensively in primary systemic vasculitis, and is suggested that this results from a systemic response that may be a consequence of primary vasculation, but is distinct from the local inflammatory vasculitic process.

TL;DR: Thalidomide provided a useful therapeutic option in severe oral and genital ulceration which had not responded to other therapies and the physician must remain vigilant to the continuing danger of axonal neuropathy and teratogenesis at all times during thalidomid therapy.