Janine Olesch

TL;DR: The relationship between current biological and clinical concepts such as cell migration modes, tumour budding and epithelial-mesenchymal transition (EMT) remains unclear in several aspects, especially for the'real' situation in human cancer as mentioned in this paper.

TL;DR: A variational approach based on a reference scan pair with reversed polarity of the phase- and frequency-encoding gradients and hence reversed distortion is presented, which provides meaningful, i.e. diffeomorphic, geometric transformations, independent of the actual choice of the regularization parameters.

TL;DR: The proposed method significantly improves the accuracy of multistain registration which allows us to compare different antibodies at cell level, and is applied to ten whole slide image pairs of human lung cancer data.

TL;DR: A novel image registration based method for reconstructing a 3D tissue block implementing a zooming strategy around a user-defined point of interest and is able to correct locally varying deformations in tissue structures and exceeds the limitations of globally linear transformations.

TL;DR: This work introduces inequality constraints, which allow for a sphere-like tolerance around each landmark, which offers the possibility to control the quality of the matching of each landmark pair individually in a variational non-parametric registration framework.