Janusz M. Dąbrowski

TL;DR: A multidisciplinary view of the issues raised by the development of PDT is presented, showing how spectroscopy, photophysics, photochemistry and pharmacokinetics of photosensitizers determine the mechanism of cell death and clinical protocols.

TL;DR: The most recent research performed on metalloporphyrin-based materials in photodynamic therapy, photodynamic inactivation of microorganisms, photodiagnosis and drug delivery are explored, demonstrating their perspectives for biomedical applications.

TL;DR: Recommendations are given for the design of more effective PDT protocols employing new halogenated and sulfonated bacteriochlorins and their analogous porphyrins as photosensitizers of singlet oxygen and the superoxide ion.

TL;DR: This work describes the bioinorganic strategies with multiple mechanisms of action based on i) small metal complexes, ii) metal modified macromolecules, iii) metal and metal oxides nanoparticles, iv) light-activated bioin organic platforms, to overcome the pathogen's resistance.

TL;DR: The spectroscopic, photophysical, and biological properties of the compounds are discussed in relevance to their PDT activity, leading to the conclusion that the bacteriochlorin derivative is a promising candidate for future in vivo experiments.