A
Alexandra H. Filipovich
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 195
Citations - 22523
Alexandra H. Filipovich is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Transplantation & Hemophagocytic lymphohistiocytosis. The author has an hindex of 73, co-authored 195 publications receiving 20178 citations. Previous affiliations of Alexandra H. Filipovich include Boston Children's Hospital & University of Cincinnati.
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Journal ArticleDOI
HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.
Jan-Inge Henter,AnnaCarin Horne,Maurizio Aricò,R. Maarten Egeler,Alexandra H. Filipovich,Shinsaku Imashuku,Stephan Ladisch,Kenneth L. McClain,David Webb,Jacek Winiarski,Gritta Janka +10 more
TL;DR: HLH‐2004 chemo‐immunotherapy includes etoposide, dexamethasone, cyclosporine A upfront and, in selected patients, intrathecal therapy with methotrexate and corticosteroids, and subsequent hematopoietic stem cell transplantation is recommended for patients with familial disease or molecular diagnosis, and patients with severe and persistent, or reactivated, disease.
Journal ArticleDOI
How I treat hemophagocytic lymphohistiocytosis
TL;DR: The clinical manifestations and patterns of HLH are reviewed and the approach to the diagnosis and therapy for this elusive and potentially lethal condition is described.
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Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia.
Vanderson Rocha,Jacqueline M. Cornish,Eric L. Sievers,Alexandra H. Filipovich,Franco Locatelli,C Peters,Mats Remberger,Gérard Michel,William Arcese,Sandro Dallorso,Karin Tiedemann,Alessandro Busca,Kawah Chan,Shunichi Kato,Juan Ortega,Marcus R. Vowels,Axel R. Zander,Gerard Souillet,Anthony Oakill,Ann E. Woolfrey,Andrea L. Pay,Ann Green,Federico Garnier,Irina Ionescu,Peter Wernet,Girolamo Sirchia,Pablo Rubinstein,Sylvie Chevret,Eliane Gluckman +28 more
TL;DR: The use of UCBT, as a source of hematopoietic stem cells, is a reasonable option for children with AL lacking an acceptably matched unrelated marrow donor.
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Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation.
Jan-Inge Henter,AnnaCarin Samuelsson-Horne,Maurizio Aricò,R. Maarten Egeler,Göran Elinder,Alexandra H. Filipovich,Helmut Gadner,Shinsaku Imashuku,Diane M. Komp,Stephan Ladisch,David Webb,Gritta Janka +11 more
TL;DR: HLH-94 is very effective, allowing BMT in most patients, and survival of children with HLH has been greatly improved.
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Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome.
Neal Flomenberg,Lee Ann Baxter-Lowe,Dennis L. Confer,Marcelo Fernandez-Vina,Alexandra H. Filipovich,Mary M. Horowitz,Carolyn Katovich Hurley,Craig Kollman,Claudio Anasetti,Harriet Noreen,Ann B. Begovich,William H. Hildebrand,Effie W. Petersdorf,B.J. Schmeckpeper,Michelle Setterholm,Elizabeth Trachtenberg,Thomas N. Williams,Edmond J. Yunis,Daniel J. Weisdorf +18 more
TL;DR: It is concluded that matching for HLA-C should be incorporated into algorithms for unrelated donor selection, and when clinical circumstances allow, high-resolution class I typing may help optimize donor selection and improve outcome.