J
Jari Leinonen
Researcher at Helsinki University Central Hospital
Publications - 40
Citations - 3348
Jari Leinonen is an academic researcher from Helsinki University Central Hospital. The author has contributed to research in topics: Prostate-specific antigen & Antigen. The author has an hindex of 26, co-authored 40 publications receiving 3287 citations. Previous affiliations of Jari Leinonen include University of Oulu & University of Helsinki.
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Journal Article
A complex between prostate-specific antigen and alpha 1-antichymotrypsin is the major form of prostate-specific antigen in serum of patients with prostatic cancer: assay of the complex improves clinical sensitivity for cancer.
TL;DR: The proportion of the PSA-alpha 1-antichymotrypsin complex was higher in patients with prostatic cancer than in those with benign hyperplasia, and assay of the complex had a higher sensitivity for cancer than assay of total PSA immunoreactivity.
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Serum concentrations of prostate specific antigen and its complex with α1-antichymotrypsin before diagnosis of prostate cancer
TL;DR: The results suggest it is advisable to confine screening for prostate cancer to men with a life expectancy of clearly more than 10 years--ie, younger men, who have the greatest chance to benefit from early detection.
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Activation of Type IV Procollagenases by Human Tumor-associated Trypsin-2*
Timo Sorsa,Tuula Salo,Erkki Koivunen,Jaana Tyynelä,Yrjö T. Konttinen,Ulrich Bergmann,Ari Tuuttila,E Niemi,Olli Teronen,Pia Heikkilä,Harald Tschesche,Jari Leinonen,Sirpa Osman,Ulf-Håkan Stenman +13 more
TL;DR: The ability of human tumor cell-derived trypsin-2 to activate latent MMPs suggests a role for trypsIn-2 in initiating the proteinase cascade that mediates tumor invasion and metastasis formation.
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Prostate-specific antigen
TL;DR: Determination of the proportion of free PSA has become widely used to improve the cancer specificity of PSA especially in men with PSA values in the 'grey zone' (4-10 microg/l).
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Purification and characterization of different molecular forms of prostate-specific antigen in human seminal fluid.
TL;DR: A new procedure for purifying prostate-specific antigen (PSA) from human seminal fluid is developed, based on ammonium sulfate precipitation, hydrophobic interaction chromatography, gel filtration, and anion-exchange chromatography.