P
Pia Heikkilä
Researcher at University of Helsinki
Publications - 26
Citations - 2004
Pia Heikkilä is an academic researcher from University of Helsinki. The author has contributed to research in topics: Medicine & Matrix metalloproteinase. The author has an hindex of 13, co-authored 17 publications receiving 1888 citations. Previous affiliations of Pia Heikkilä include Helsinki University Central Hospital.
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Journal ArticleDOI
Tumor targeting with a selective gelatinase inhibitor
Erkki Koivunen,Wadih Arap,Heli Valtanen,Aija Rainisalo,Oula Penate Medina,Pia Heikkilä,Carmela Kantor,Carl G. Gahmberg,Tuula Salo,Yrjö T. Konttinen,Timo Sorsa,Erkki Ruoslahti,Renata Pasqualini +12 more
TL;DR: It is shown that cyclic peptides containing the sequence HWGF are potent and selective inhibitors of M MP-2 and MMP-9 but not of several other MMP family members, and its prototype synthetic peptide, CTTHWGFTLC, inhibits the migration of human endothelial cells and tumor cells.
Journal ArticleDOI
Activation of Type IV Procollagenases by Human Tumor-associated Trypsin-2*
Timo Sorsa,Tuula Salo,Erkki Koivunen,Jaana Tyynelä,Yrjö T. Konttinen,Ulrich Bergmann,Ari Tuuttila,E Niemi,Olli Teronen,Pia Heikkilä,Harald Tschesche,Jari Leinonen,Sirpa Osman,Ulf-Håkan Stenman +13 more
TL;DR: The ability of human tumor cell-derived trypsin-2 to activate latent MMPs suggests a role for trypsIn-2 in initiating the proteinase cascade that mediates tumor invasion and metastasis formation.
Journal ArticleDOI
Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases
Ritva Heljasvaara,Pia Nyberg,Jani Luostarinen,Mataleena Parikka,Pia Heikkilä,Marko Rehn,Timo Sorsa,Tuula Salo,Taina Pihlajaniemi +8 more
TL;DR: The results indicate that certain, especially cancer-related, MMP family members can generate biologically active endostatin-containing polypeptides from collagen XVIII and thus, by releasing endstatin fragments, may participate in the inhibition of endothelial cell proliferation, migration and angiogenesis.
Journal ArticleDOI
MMP inhibition and downregulation by bisphosphonates.
Olli Teronen,Pia Heikkilä,Yrjö T. Konttinen,Minna Laitinen,Tuula Salo,Roeland Hanemaaijer,Anneli Teronen,Päivi Maisi,Timo Sorsa +8 more
TL;DR: It is discovered that various matrix metalloproteinases (MMPs) are inhibited in vitro by several bisphosphonates, which has the potential to become one of the main MMP‐inhibitors for MMP-related human soft and hard tissue‐destructive diseases in the near future.
Journal ArticleDOI
Endostatin inhibits human tongue carcinoma cell invasion and intravasation and blocks the activation of matrix metalloprotease-2, -9, and -13.
Pia Nyberg,Pia Heikkilä,Timo Sorsa,Jani Luostarinen,Ritva Heljasvaara,Ulf-Håkan Stenman,Taina Pihlajaniemi,Tuula Salo,Tuula Salo +8 more
TL;DR: The results show that endostatin blocks the activation and activities of certain tumor-associated pro-MMPs, such as pro- MMP-2, -9, and -13, which may explain, at least in part, the antitumor effect ofendostatin.