M
Martin Enge
Researcher at Karolinska Institutet
Publications - 43
Citations - 8350
Martin Enge is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 18, co-authored 34 publications receiving 7061 citations. Previous affiliations of Martin Enge include Stanford University & Science for Life Laboratory.
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Journal ArticleDOI
DNA-Binding Specificities of Human Transcription Factors
Arttu Jolma,Jian Yan,Tom Whitington,Jarkko Toivonen,Kazuhiro R. Nitta,Pasi Rastas,Ekaterina Morgunova,Martin Enge,Mikko Taipale,Gong-Hong Wei,Kimmo Palin,Juan M. Vaquerizas,Renaud Vincentelli,Nicholas M. Luscombe,Timothy P. Hughes,Patrick Lemaire,Esko Ukkonen,Teemu Kivioja,Teemu Kivioja,Jussi Taipale,Jussi Taipale +20 more
TL;DR: Global analysis of the data revealed that homodimer orientation and spacing preferences, and base-stacking interactions, have a larger role in TF-DNA binding than previously appreciated.
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A survey of human brain transcriptome diversity at the single cell level
Spyros Darmanis,Steven A. Sloan,Ye Zhang,Martin Enge,Christine Caneda,Lawrence M. Shuer,Melanie Hayden Gephart,Ben A. Barres,Stephen R. Quake +8 more
TL;DR: The first, to the authors' knowledge, single cell whole transcriptome analysis of human adult cortical samples is described, establishing an experimental and analytical framework with which the complexity of the human brain can be dissected on the single cell level.
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Counting absolute numbers of molecules using unique molecular identifiers
Teemu Kivioja,Anna Vähärautio,Anna Vähärautio,Kasper Karlsson,Martin Bonke,Martin Enge,Sten Linnarsson,Jussi Taipale +7 more
TL;DR: Unique molecular identifiers (UMIs), which make each molecule in a population distinct, are applied to genome-scale human karyotyping and mRNA sequencing in Drosophila melanogaster to improve accuracy of almost any next-generation sequencing method.
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Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.
Natalia Issaeva,Przemyslaw Bozko,Martin Enge,Marina Protopopova,Lisette G.G.C. Verhoef,Maria G. Masucci,Aladdin Pramanik,Galina Selivanova +7 more
TL;DR: RITA prevented p53–HDM-2 interaction in vitro and in vivo and affected p53 interaction with several negative regulators and may serve as a lead compound for the development of an anticancer drug that targets tumors with wild-type p53.
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MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.
Netta Mäkinen,Miika Mehine,Jaana Tolvanen,Eevi Kaasinen,Yang Li,Heli J. Lehtonen,Massimiliano Gentile,Jian Yan,Martin Enge,Minna Taipale,Minna Taipale,Mervi Aavikko,Riku Katainen,Elina Virolainen,Tom Böhling,Tom Böhling,Taru A. Koski,Virpi Launonen,Jari Sjöberg,Jussi Taipale,Jussi Taipale,Pia Vahteristo,Lauri A. Aaltonen +22 more
TL;DR: It is determined that MED12 is altered in 70% (159 of 225) of tumors from a total of 80 patients, and aberrant function of this region of MED12 contributes to tumorigenesis.