Jason A. Burdick

TL;DR: A class of hydrogels that leverage the favorable properties of the photo-cross-linkable hyaluronic acid (HA) and semi-interpenetrating collagen components and far surpass those achievable with collagen gels or collagen gel-based semi-IPNs are presented.

TL;DR: A novel process that utilizes different crosslinking mechanisms to provide gel environments that are either permissive or inhibitory to cellular spreading is developed, both to provide new insights into the relationships between gel structure and cell behavior, and for eventual tissue-engineering applications where spatial control over cells is desired.

TL;DR: In this paper, the authors developed a bioprinting approach to transfer spheroids into self-healing support hydrogels at high resolution, which enables their patterning and fusion into high-cell density microtissues of prescribed spatial organization.

TL;DR: An in vitro model whereby molded tubular channels inside a synthetic hydrogel are seeded with endothelial cells and subjected to chemokine gradients within a microfluidic device is developed and it is found that matrix degradability modulates the collectivity of cell migration.

TL;DR: For the first time, a new macromer allows for enhanced control over the structural evolution of the HA hydrogels toward applications as biomaterials.