Jason A. Burdick

TL;DR: It is shown that the signaling pathways of vascular morphogenesis of ECFCs can be precisely regulated in a synthetic matrix, resulting in a functional microvasculature useful for the study of 3-dimensional vascular biology and toward a range of vascular disorders and approaches in tissue regeneration.

TL;DR: This study systematically examined the dynamics of motor clutches formed between the cell and a viscoelastic substrate using analytical methods and direct Monte Carlo simulation and found that intermediate viscosity maximizes cell spreading on soft substrates, while cell spreading is independent of Viscosity on stiff substrates.

TL;DR: This work develops the first combinatorial library of degradable photocrosslinked materials, a library of Krylate-terminated polymers with diverse properties such as cadmium, cadmiferous material, and polymethine.

TL;DR: 3D‐printing is emerging as a technology to introduce microchannels into hydrogels, for the perfusion of engineered constructs and can be used for a range of biomedical applications, from engineering vascularized tissue constructs to modeling in vitro cultures.

TL;DR: The development and application of an injectable hyaluronic acid hydrogel for the local and sustained delivery of miR-302 mimics to the heart promotes cardiomyocyte proliferation and improves cardiac function in mice after myocardial infarction suggests that biomaterial-based miRNA delivery systems can lead to improved outcomes via cardiac regeneration after myocardIAL infarctions.