J
Jason A. Burdick
Researcher at University of Pennsylvania
Publications - 363
Citations - 42498
Jason A. Burdick is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Self-healing hydrogels & Tissue engineering. The author has an hindex of 103, co-authored 335 publications receiving 34137 citations. Previous affiliations of Jason A. Burdick include Duke University & University of Kentucky.
Papers
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Journal ArticleDOI
Injectable Supramolecular Hydrogel/Microgel Composites for Therapeutic Delivery.
Minna H. Chen,Jennifer J. Chung,Joshua E. Mealy,Samir Zaman,Elizabeth C. Li,Maria F. Arisi,Pavan Atluri,Jason A. Burdick +7 more
TL;DR: In a rat model of MI, composites with IL-10 reduce macrophage density and improve scar thickness, ejection fraction, cardiac output, and the size of vascular structures after 4 weeks when compared to saline injection, emphasizing the role of injectable hydrogels alone on tissue repair.
Patent
Stabilizing shear-thinning hydrogels
TL;DR: In this paper, settable, shear-thinning hydrogels, each hydrogel comprising a hydrophilic polymer network, is triggerable to cross-link by the application of a stimulus.
Journal ArticleDOI
Local immunotherapy via delivery of interleukin-10 and transforming growth factor β antagonist for treatment of chronic kidney disease.
Christopher B. Rodell,Reena Rai,Sarah Faubel,Jason A. Burdick,Danielle E. Soranno,Danielle E. Soranno +5 more
TL;DR: Results demonstrated reduced macrophage infiltration beyond day 7 in treatment groups and reduced apoptosis at day 21, relative to untreated unilateral ureteral obstruction disease model, and dual delivery of IL-10 and anti-TGFβ resulted in a paradoxical hastening of fibrosis, warranting further investigation.
Journal ArticleDOI
Modification of Infarct Material Properties Limits Adverse Ventricular Remodeling
Masato Morita,Chad E. Eckert,Kanji Matsuzaki,Mio Noma,Liam P. Ryan,Jason A. Burdick,Benjamin M. Jackson,Joseph H. Gorman,Michael S. Sacks,Robert C. Gorman +9 more
TL;DR: Durable infarct thickening and stiffening can be achieved by infarCT biomaterial injection, resulting in the amelioration of infarctor expansion and global LV remodeling.
Journal ArticleDOI
Improved cartilage repair via in vitro pre-maturation of MSC-seeded hyaluronic acid hydrogels
Isaac E. Erickson,Sydney R. Kestle,Kilief H. Zellars,George R. Dodge,Jason A. Burdick,Robert L. Mauck +5 more
TL;DR: Assessment of the maturation and integration of mesenchymal stem cell (MSC) hydrogels in an in vitro cartilage defect model indicates that construct pre-maturation may be an essential element of functional cartilage repair.