Jason Ho

TL;DR: Genomic deletions in PLCG2 cause gain of PLCγ(2) function, leading to signaling abnormalities in multiple leukocyte subsets and a phenotype encompassing both excessive and deficient immune function.

TL;DR: Investigation of B cells before and after reduction of HIV plasma viremia by antiretroviral therapy provides new insights on B cells in HIV infection and how early initiation of ART may prevent irreversible immune system damage.

TL;DR: It is shown that downregulation of B cell inhibitory receptors in primary human B cells led to increased tissue-like memory B cell proliferation and responsiveness against HIV.

TL;DR: High extrinsic CD95 ligand (CD95L)-mediated apoptosis in CD10−/CD21lo mature/activated B cells that likely arise from HIV-induced immune activation is described and both may contribute to the depletion and dysfunction of B cells in these individuals.

TL;DR: The data suggest that while plasmablasts in the blood may contribute to the HIV-specific immune response, the majority of these cells are not HIV specific and arise early, likely from indirect immune-activating effects of HIV replication, and reflect over time the effects of chronic antigenic stimulation.