Jason M. White

TL;DR: Moderate-quality evidence was found that alpha2-adrenergic agonists were more effective than placebo in ameliorating withdrawal in terms of the likelihood of severe withdrawal, and peak withdrawal severity may be greater with alpha2/adrenaline agonists than with reducing doses of methadone.

TL;DR: In this article, the authors examined the relationship between the prevalence and concentration of drugs and the culpability of the driver using an objective method for assessing culpability, and found a significant concentration-dependent relationship between alcohol and culpability: as blood alcohol concentration increased, so did the percentage of culpable drivers.

TL;DR: Increased exposure to opioid maintenance treatment reduces the risk of death in opioid-dependent people and there was no differential mortality among methadone versus buprenorphine participants.

TL;DR: It is proposed that the current means of responding to emerging substances might no longer be fit for purpose in a world in which different substances can be rapidly introduced, and where people who use drugs can change preferences on the basis of market availability.

TL;DR: The findings suggest that methadone patients are cross‐tolerant to the antinociceptive effects of morphine, and conventional doses of morphine are likely to be ineffective in managing episodes of acute pain amongst this patient group.