J
Jason S. Biggs
Researcher at University of Guam
Publications - 30
Citations - 893
Jason S. Biggs is an academic researcher from University of Guam. The author has contributed to research in topics: Conus & Sponge. The author has an hindex of 15, co-authored 28 publications receiving 717 citations. Previous affiliations of Jason S. Biggs include University of Hawaii at Manoa & Weizmann Institute of Science.
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Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges
Vinayak Agarwal,Jessica M. Blanton,Sheila Podell,Arnaud Taton,Michelle Schorn,Julia Busch,Zhenjian Lin,Eric W. Schmidt,Paul R. Jensen,Valerie J. Paul,Jason S. Biggs,James W. Golden,Eric E. Allen,Bradley S. Moore +13 more
TL;DR: The results establish the genetic and molecular foundation for the production of PBDEs in one of the most abundant natural sources of these molecules, further setting the stage for a metagenomic-based inventory of other PBDE sources in the marine environment.
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Isolation, Structure Determination, and Biological Activity of Dolastatin 12 and Lyngbyastatin 1 from Lyngbya majuscula/Schizothrix calcicola Cyanobacterial Assemblages
George G. Harrigan,Wesley Y. Yoshida,Richard E. Moore,Dale G. Nagle,Dale G. Nagle,Peter U. Park,Jason S. Biggs,Valerie J. Paul,Susan L. Mooberry,Thomas H. Corbett,Fred Valeriote +10 more
TL;DR: Both 1ab and 2ab were shown to be potent disrupters of cellular microfilament networks and proved toxic with only marginal or no antitumor activity when tested against colon adenocarcinoma #38 or mammary adenOCarcinomas #16/C.
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Potent Elastase Inhibitors from Cyanobacteria: Structural Basis and Mechanisms Mediating Cytoprotective and Anti-inflammatory Effects in Bronchial Epithelial Cells
Lilibeth A. Salvador,Kanchan Taori,Jason S. Biggs,Jean Jakoncic,David A. Ostrov,Valerie J. Paul,Hendrik Luesch +6 more
TL;DR: A novel and representative family member, symplostatin 5 (1), is probed, which attenuated the downstream cellular effects of elastase in an epithelial lung airway model system, alleviating clinical hallmarks of chronic pulmonary diseases such as cell death, cell detachment, and inflammation.
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Veraguamides A−G, Cyclic Hexadepsipeptides from a Dolastatin 16-Producing Cyanobacterium Symploca cf. hydnoides from Guam
TL;DR: Preliminary structure-activity relationship analysis identified several sensitive positions in the veraguamide scaffold that affect the cytotoxic activity of this compound class.
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Evolution of Conus peptide toxins: Analysis of Conus californicus Reeve, 1844
Jason S. Biggs,Maren Watkins,Nicolas Puillandre,John Paul Ownby,Estuardo López-Vera,Estuardo López-Vera,Sean Christensen,Karla Juarez Moreno,Johanna Bernáldez,Alexei F. Licea-Navarro,Patrice Showers Corneli,Baldomero M. Olivera +11 more
TL;DR: The phylogenies of the genus, based on mitochondrial genes, confirm previous results that C. californicus is highly divergent from all other species and demonstrate that, unlike endogenously acting gene families, these genes are likely to be significantly more restricted in their phylogenetic distribution.