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Javier A. Menendez

Researcher at NorthShore University HealthSystem

Publications -  336
Citations -  29348

Javier A. Menendez is an academic researcher from NorthShore University HealthSystem. The author has contributed to research in topics: Cancer & Fatty acid synthase. The author has an hindex of 73, co-authored 317 publications receiving 25654 citations. Previous affiliations of Javier A. Menendez include Northwestern University & Boston Biomedical Research Institute.

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Journal ArticleDOI

Sequence-dependent synergism and antagonism between paclitaxel and gemcitabine in breast cancer cells: the importance of scheduling.

Cristina Oliveras-Ferraros, +5 more
- 01 Jan 2008 - 
TL;DR: The occurrence of clinically relevant synergism between PTX and GEM suggests a sequence-dependent nature in human breast cancer cells.
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The promiscuous and synergic molecular interaction of polyphenols in bactericidal activity: an opportunity to improve the performance of antibiotics?

Laura Tomás-Menor, +7 more
- 01 Mar 2015 - 
TL;DR: The rational optimization of these combinations could lead to the design of potent antimicrobial phytopharmaceuticals, which may improve the performance of current antibiotics, taking advantage of the multi‐targeted and synergic molecular interactions of selected polyphenols.
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Dietary fatty acids regulate the activation status of Her-2/neu (c-erbB-2) oncogene in breast cancer cells

Javier A. Menendez, +3 more
- 01 Nov 2004 - 
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Does endogenous fatty acid metabolism allow cancer cells to sense hypoxia and mediate hypoxic vasodilatation? Characterization of a novel molecular connection between fatty acid synthase (FAS) and hypoxia-inducible factor-1α (HIF-1α)-related expression of vascular endothelial growth factor (VEGF) in cancer cells overexpressing Her-2/neu oncogene

Javier A. Menendez, +5 more
- 01 Apr 2005 - 
TL;DR: In this article, a bi-directional molecular connection between Her-2/neu and FAS-dependent neoplastic lipogenesis is investigated, and it is shown that perturbation of cancer-associated endogenous fatty metabolism triggers a "hypoxia-like" (oxygen-independent) condition that actively rescues Her2/NEu-dependent MAPK --> HIP-1alpha --> VEGF cascade.
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Uptake and metabolism of olive oil polyphenols in human breast cancer cells using nano-liquid chromatography coupled to electrospray ionization-time of flight-mass spectrometry.

Rocío García-Villalba, +5 more
- 01 Jun 2012 - 
TL;DR: A nano liquid chromatography-electrospray ionization-time of flight mass spectrometry method was developed to study the cellular uptake and metabolism of olive oil phenols in JIMT-1 human breast cancer cells, suggesting a catalytic action of catechol-O-methyl transferase (COMT) in cancer cells.