J
Javier A. Menendez
Researcher at NorthShore University HealthSystem
Publications - 336
Citations - 29348
Javier A. Menendez is an academic researcher from NorthShore University HealthSystem. The author has contributed to research in topics: Cancer & Fatty acid synthase. The author has an hindex of 73, co-authored 317 publications receiving 25654 citations. Previous affiliations of Javier A. Menendez include Northwestern University & Boston Biomedical Research Institute.
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Journal ArticleDOI
Direct antitumour activity of zoledronic acid: preclinical and clinical data.
TL;DR: This review summarises the published data on antitumour effects of ZA in tumour cell lines, mice experiments, and human clinical trials and translational questions regarding drug dose, dose interval, and sequence with chemotherapy treatment are addressed.
Journal ArticleDOI
Metformin Potentiates the Benefits of Dietary Restraint: A Metabolomic Study
Marta Riera-Borrull,Anabel García-Heredia,Salvador Fernández-Arroyo,Anna Hernández-Aguilera,Noemí Cabré,Elisabet Cuyàs,Fedra Luciano-Mateo,Jordi Camps,Javier A. Menendez,Jorge Joven +9 more
TL;DR: Mice treated with metformin and diet-reversal showed dramatically improved protection against HFD-induced hepatic steatosis, a beneficial effect that was accompanied by a lowering of liver-infiltrating pro-inflammatory macrophages and lower release of pro- inflammatory cytokines.
Journal ArticleDOI
Metformin and Breast Cancer: Where Are We Now?
TL;DR: The current state of the art of metformin mechanisms of action is revisited, past and current met formin-based clinical trials are critically reviewed, and future perspectives on how to incorporate meetformin into the oncologist’s armamentarium for the prevention and treatment of breast cancer are discussed.
Journal ArticleDOI
Heregulin-triggered Her-2/neu signaling enhances nuclear accumulation of p21WAF1/CIP1 and protects breast cancer cells from cisplatin-induced genotoxic damage.
TL;DR: It is suggested that one mechanism of HRG-regulated breast cancer cell proliferation, survival, and/or sensitivity to genotoxic damage is to stabilize and promote a nuclear accumulation of p21WAF1/CIP1.
Book ChapterDOI
Her-2/neu-induced "cytokine signature" in breast cancer.
TL;DR: Enhanced synthesis and secretion of members of the IL-8/GRO chemokine family, which have recently been linked to estrogen receptor (ER) inaction, increased cell invasion, and angiogenesis, may represent a new pathway involved in the metastatic progression and endocrine resistance of HER2-overexpressing breast carcinomas.