J
Javier A. Menendez
Researcher at NorthShore University HealthSystem
Publications - 336
Citations - 29348
Javier A. Menendez is an academic researcher from NorthShore University HealthSystem. The author has contributed to research in topics: Cancer & Fatty acid synthase. The author has an hindex of 73, co-authored 317 publications receiving 25654 citations. Previous affiliations of Javier A. Menendez include Northwestern University & Boston Biomedical Research Institute.
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Journal ArticleDOI
One-carbon metabolism: An aging-cancer crossroad for the gerosuppressant metformin
Javier A. Menendez,Jorge Joven +1 more
TL;DR: In this article, the authors provide a perspective on recent findings suggesting that de novo biosynthesis of purine nucleotides, which is based on the metabolism of one-carbon compounds, is a new target for metformin's actions at the crossroads of aging and cancer.
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Senescence-Inflammatory Regulation of Reparative Cellular Reprogramming in Aging and Cancer.
Javier A. Menendez,Tomás Alarcón +1 more
TL;DR: The consideration of a cellular reprogramming-centered view of epigenetic plasticity as a fundamental element of a tissue's capacity to undergo successful repair, aging degeneration or malignant transformation should provide challenging stochastic insights into the current deterministic genetic paradigm for most chronic diseases.
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Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A
Elisabet Cuyàs,Juan Gumuzio,Jesús Lozano-Sánchez,David Carreras,Sara Verdura,Laura Llorach-Parés,Melchor Sanchez-Martinez,Elisabet Selga,Guillermo J. Pérez,Fabiana S. Scornik,Ramon Brugada,Joaquim Bosch-Barrera,Antonio Segura-Carretero,Angel G. Martin,José Antonio Encinar,Javier A. Menendez +15 more
TL;DR: These findings provide the first evidence that EVOO contains a naturally occurring phenolic inhibitor of LSD1, and support the use of oleacein as a template to design new secoiridoid-based LSD1 inhibitors.
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The extra virgin olive oil phenolic oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase.
Elisabet Cuyàs,Sara Verdura,Jesús Lozano-Sánchez,Ignacio Viciano,Laura Llorach-Parés,Alfons Nonell-Canals,Joaquim Bosch-Barrera,Joan Brunet,Antonio Segura-Carretero,Melchor Sanchez-Martinez,José Antonio Encinar,Javier A. Menendez +11 more
TL;DR: A theoretical determination of how EVOO dihydroxy-phenols can be metabolized via COMT is provided, which adds a new dimension to the physiological and therapeutic utility of EVOO secoiridoids.
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Polo-like kinase 1 directs the AMPK-mediated activation of myosin regulatory light chain at the cytokinetic cleavage furrow independently of energy balance
TL;DR: A previously unrecognized role for AMPK is proposed in ensuring that cytokinesis occurs at the proper place and time by establishing a molecular dialog between PLK1 and MRLC in an energy-independent manner.