J
Javier A. Menendez
Researcher at NorthShore University HealthSystem
Publications - 336
Citations - 29348
Javier A. Menendez is an academic researcher from NorthShore University HealthSystem. The author has contributed to research in topics: Cancer & Fatty acid synthase. The author has an hindex of 73, co-authored 317 publications receiving 25654 citations. Previous affiliations of Javier A. Menendez include Northwestern University & Boston Biomedical Research Institute.
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Journal ArticleDOI
Androgen-independent prostate cancer cells circumvent EGFR inhibition by overexpression of alternative HER receptors and ligands
Dolors Carrion-Salip,Clara Panosa,Javier A. Menendez,Teresa Puig,Glòria Oliveras,Atanasio Pandiella,Rafael de Llorens,Anna Massaguer +7 more
TL;DR: The results confirm that the overexpression and autocrine activation of HER3 play a key role in mediating the resistance to EGFR inhibitors in androgen-independent PCa cells.
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Stem cell property epithelial-to-mesenchymal transition is a core transcriptional network for predicting cetuximab (Erbitux™) efficacy in KRAS wild-type tumor cells.
Cristina Oliveras-Ferraros,Alejandro Vazquez-Martin,Sílvia Cufí,Bernardo Queralt,Luciana Báez,Raquel Guardeño,Xavier Hernández-Yagüe,Begoña Martin-Castillo,Joan Brunet,Javier A. Menendez +9 more
TL;DR: Quantitative real‐time PCR, high‐content immunostaining, and flow‐cytometry analyses confirmed that CTX efficacy depends on its ability to promote stronger cell–cell contacts by up‐regulating the expression of the epithelial markers E‐cadherin and occludin.
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A phase 2 trial of neoadjuvant metformin in combination with trastuzumab and chemotherapy in women with early HER2-positive breast cancer: the METTEN study.
Begoña Martin-Castillo,Sonia Pernas,Joan Dorca,Isabel Alvarez,Susana Martínez,Jose Perez-Garcia,N. Batista-López,César A Rodríguez-Sánchez,Kepa Amillano,Severina Domínguez,M. Luque,Agostina Stradella,Idoia Morilla,Gemma Viñas,Javier Cortes,Elisabet Cuyàs,Sara Verdura,Álvaro Fernández-Ochoa,Salvador Fernández-Arroyo,Antonio Segura-Carretero,Jorge Joven,Elsa Pérez,Neus Bosch,Margarita Garcia,Eugeni López-Bonet,Samiha Saidani,Maria Buxó,Javier A. Menendez +27 more
TL;DR: Addition of anti-diabetic doses of metformin to a complex neoadjuvant regimen was well tolerated and safe and should be interpreted with caution.
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Metformin directly targets the H3K27me3 demethylase KDM6A/UTX.
Elisabet Cuyàs,Sara Verdura,Laura Llorach-Parés,Salvador Fernández-Arroyo,Fedra Luciano-Mateo,Noemí Cabré,Jan Stursa,Lukas Werner,Begoña Martin-Castillo,Benoit Viollet,Jiri Neuzil,Jiri Neuzil,Jorge Joven,Alfons Nonell-Canals,Melchor Sanchez-Martinez,Javier A. Menendez +15 more
TL;DR: A systematic chemoinformatics approach coupled to experimental validation reveals that metformin might directly regulate the biological machinery of aging by targeting core chromatin modifiers of the epigenome.
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Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells.
TL;DR: This is the first study demonstrating that breast cancer-associated FAS is playing an active role in human breast cancer chemosensitivity and suggests that pharmacological inhibition of FAS activity is a novel molecular approach to enhance the cytotoxic effects of existing chemotherapeutic agents inhuman breast cancer.