Jay Tracy

TL;DR: It is established that antibodies against beta-amyloid plaques can slow cognitive decline in patients with Alzheimer's disease.

TL;DR: Generation of functional TEHV from human MSC was feasible utilizing a biomimetic in vitro environment and the neo-tissue showed morphological features and mechanical properties of human native-heart-valve tissue.

TL;DR: It appears that UCC represent a promising alternative autologous cell source for cardiovascular tissue engineering, offering the additional benefits of using juvenile cells and avoiding the invasive harvesting of intact vascular structures.

TL;DR: The results provide the evidence that lowering of brain Abeta levels by increasing its degradation can improve cognitive functions in vivo, and suggest that increasing the activity of neprilysin in brain may be effective in preventing cognitive decline in AD.

TL;DR: Neuronal upregulation of neprilysin (NEP) in young transgenic mice expressing the AD‐causing amyloid precursor protein mutations (SwAPP) led to reduction of brain Aβ levels and delayed Aβ plaque deposition, suggesting that the potential of NEP for AD therapy is age‐dependent and most effective early in the course of AD pathophysiology.