Je-Tae Woo

TL;DR: Calcineurin is defined as an essential downstream effector of the RANKL-induced signal transduction pathway leading toward the induction of osteoclast differentiation and indicates that the activation of the NFATc1 transcription factor is sufficient to initiate a genetic program that results in the specification of the mature functional osteOClast cell phenotype.

TL;DR: The mechanism that make catechins cytotoxic in certain tumor cells is due to their ability to produce H(2)O( 2) and that the resulting increase in H-O-2 levels triggers Fe(II)-dependent formation of highly toxic hydroxyl radical, which in turn induces apoptotic cell death.

TL;DR: The present results suggest that nobiletin improved the hyperglycemia and insulin resistance in obese diabetic ob/ob mice by regulating expression of Glut1 and Glut4 in WAT and muscle, and expression of adipokines in W AT.

TL;DR: Results indicate that the Fenton reaction is primarily involved in EGCG-induced osteoclastic cell death, which is associated with osteoporosis.

TL;DR: The results suggest that IL-1 as well as LPS stimulates osteoclastogenesis through two parallel events: direct enhancement of RANKL expression and suppression of OPG expression, which is mediated by PGE2 production.