J
Jean-Christophe Lagier
Researcher at Aix-Marseille University
Publications - 311
Citations - 17625
Jean-Christophe Lagier is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Genome & Medicine. The author has an hindex of 50, co-authored 274 publications receiving 13861 citations. Previous affiliations of Jean-Christophe Lagier include Institut de recherche pour le développement & Centre national de la recherche scientifique.
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Journal ArticleDOI
Clostridium butyricum Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates
Nadim Cassir,Samia Benamar,Jacques Yaacoub Bou Khalil,Olivier Croce,Marie Saint-Faust,Aurélien Jacquot,Matthieu Million,Saïd Azza,Nicholas Armstrong,Mireille Henry,Priscilla Jardot,Catherine Robert,Catherine Gire,Jean-Christophe Lagier,Eric Chabrière,Eric Ghigo,Hélène Marchandin,C. Sartor,Patrick Boutte,Gilles Cambonie,Umberto Simeoni,Didier Raoult,Bernard La Scola +22 more
TL;DR: NEC was associated with C. butyricum strains and dysbiosis with an oxidized, acid, and poorly diversified gut microbiota, and the findings highlight the plausible toxigenic mechanism involved in the pathogenesis of NEC.
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Early Fecal Microbiota Transplantation Improves Survival in Severe Clostridium difficile Infections
Marie Hocquart,Jean-Christophe Lagier,Nadim Cassir,Nadia Saidani,Carole Eldin,Jad Kerbaj,Marion Delord,Camille Valles,Philippe Brouqui,Didier Raoult,Matthieu Million +10 more
TL;DR: Early FMT dramatically reduces mortality and should be proposed as a first-line treatment for severe CDI patients, particularly those with severe infection.
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Treatment of classic Whipple's disease: from in vitro results to clinical outcome
Jean-Christophe Lagier,Florence Fenollar,Hubert Lepidi,Roch Giorgi,Matthieu Million,Didier Raoult +5 more
TL;DR: In vitro results were confirmed by clinical outcomes and trimethoprim/sulfamethoxazole was associated with failures and the recommended management is a combination of doxycycline and hydroxychloroquine for 1 year, followed by doxy cycline for the patient's lifetime along with stringent therapeutic drug monitoring.
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Tropheryma whipplei and Whipple's disease
TL;DR: Doxycycline and hydroxychloroquine for 12 months is the best treatment for Whipple's disease; it should be followed by life-long treatment with doxycycline, as potentially fatal relapses can occur.
Journal ArticleDOI
Non-contiguous finished genome sequence and description of Alistipes ihumii sp. nov.
Anne Pfleiderer,Ajay Kumar Mishra,Jean-Christophe Lagier,Catherine Robert,Aurelia Caputo,Didier Raoult,Didier Raoult,Pierre-Edouard Fournier +7 more
TL;DR: The genome of A. ihumii strain AP11T sp.