J
Jean-Christophe Lagier
Researcher at Aix-Marseille University
Publications - 311
Citations - 17625
Jean-Christophe Lagier is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Genome & Medicine. The author has an hindex of 50, co-authored 274 publications receiving 13861 citations. Previous affiliations of Jean-Christophe Lagier include Institut de recherche pour le développement & Centre national de la recherche scientifique.
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Journal ArticleDOI
Failure and relapse after treatment with trimethoprim/sulfamethoxazole in classic Whipple's disease
TL;DR: It is confirmed, as predicted from prior testing of T. whipplei susceptibility, that trimethoprim/sulfamethoxazole is not optimal for classic Whipple's disease, and 1 year treatment may be followed by relapses.
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Culturomics and pyrosequencing evidence of the reduction in gut microbiota diversity in patients with broad-spectrum antibiotics.
Grégory Dubourg,Jean-Christophe Lagier,Catherine Robert,Fabrice Armougom,Perrine Hugon,Sarah Metidji,Niokhor Dione,Nicole Prisca Makaya Dangui,Anne Pfleiderer,Jônatas Santos Abrahão,Didier Musso,Laurent Papazian,Philippe Brouqui,Fehmida Bibi,Muhammad Yasir,Bernard Vialettes,Didier Raoult,Didier Raoult +17 more
TL;DR: Stool samples studied showed a dramatic reduction in bacterial diversity, possibly linked to the production of bacteriocin in the upper digestive tract by specific bacteria, such as Lactobacillus spp.
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Genome sequence and description of Aeromicrobium massiliense sp. nov.
Dhamodharan Ramasamy,Sahare Kokcha,Jean-Christophe Lagier,Thi-Thien Nguyen,Didier Raoult,Pierre-Edouard Fournier +5 more
TL;DR: The features of this organism are described, together with the complete genome sequence and annotation, and the 3,322,119 bp long genome contains 3,296 protein-coding and 51 RNA genes.
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Non contiguous-finished genome sequence and description of Enterobacter massiliensis sp. nov.
Jean-Christophe Lagier,Khalid El Karkouri,Ajay Kumar Mishra,Catherine Robert,Didier Raoult,Pierre-Edouard Fournier +5 more
TL;DR: The genome of E. massiliensis strain JC163T was isolated from the fecal flora of a healthy Senegalese patient and contains 4,644 protein-coding and 80 RNA genes, including 5 rRNA genes.
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Clinical Efficacy of Chloroquine derivatives in COVID-19 Infection: Comparative meta-analysis between the Big data and the real world
Matthieu Million,Philippe Gautret,Philippe Colson,Yanis Roussel,Grégory Dubourg,Eric Chabrière,Stéphane Honoré,Jean-Marc Rolain,Florence Fenollar,Pierre-Edouard Fournier,Jean-Christophe Lagier,Philippe Parola,Philippe Brouqui,Didier Raoult +13 more
TL;DR: It is demonstrated that chloroquine derivatives are effective to improve clinical and virological outcomes, but, more importantly, they reduce mortality by a factor of 3 in patients with COVID-19.