J
Jean-Luc Murk
Researcher at Utrecht University
Publications - 48
Citations - 2050
Jean-Luc Murk is an academic researcher from Utrecht University. The author has contributed to research in topics: Progressive multifocal leukoencephalopathy & Medicine. The author has an hindex of 18, co-authored 44 publications receiving 1620 citations. Previous affiliations of Jean-Luc Murk include St. Elizabeth Hospital & Erasmus University Rotterdam.
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Journal ArticleDOI
Tubuloids derived from human adult kidney and urine for personalized disease modeling
Frans Schutgens,Frans Schutgens,Maarten B. Rookmaaker,Thanasis Margaritis,Anne C. Rios,Carola Ammerlaan,Carola Ammerlaan,Jitske Jansen,Linda Gijzen,Marianne K. Vormann,Annelotte M. Vonk,Marco C. Viveen,Fjodor A. Yousef Yengej,Fjodor A. Yousef Yengej,Sepide Derakhshan,Karin M. de Winter-de Groot,Benedetta Artegiani,Ruben van Boxtel,Edwin Cuppen,Antoni P. A. Hendrickx,Marry M. van den Heuvel-Eibrink,Ellen Heitzer,Henriëtte L. Lanz,Jeffrey M. Beekman,Jean-Luc Murk,Rosalinde Masereeuw,Frank C. P. Holstege,Jarno Drost,Marianne C. Verhaar,Hans Clevers +29 more
TL;DR: Conditions for the long-term growth of primary kidney tubular epithelial organoids, or ‘tubuloids’, are described and tubuloids grown from human kidney tissue and urine aid the study of BK virus infection, Wilms tumors and cystic fibrosis.
Journal ArticleDOI
Influence of aldehyde fixation on the morphology of endosomes and lysosomes: quantitative analysis and electron tomography.
Jean-Luc Murk,George Posthuma,Abraham J. Koster,Hans J. Geuze,Arie J. Verkleij,Monique J. Kleijmeer,Bruno M. Humbel +6 more
TL;DR: It is found that aldehyde fixation causes a significant deformation and reduction of endosomal volume without affecting the membrane length, and the implications for the interpretation of immunogold localization studies on chemically fixed cells are discussed.
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Involvement of the Endoplasmic Reticulum in Peroxisome Formation
Hans J. Geuze,Jean-Luc Murk,An K. Stroobants,Janice Griffith,Monique J. Kleijmeer,Abraham J. Koster,Arie J. Verkleij,Ben Distel,Henk F. Tabak +8 more
TL;DR: Evidence supporting the involvement of the endoplasmic reticulum (ER) in peroxisome formation is presented by electron microscopy, immunocytochemistry and three-dimensional image reconstruction ofperoxisomes and associated compartments in mouse dendritic cells.
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Endosomal compartmentalization in three dimensions: Implications for membrane fusion
Jean-Luc Murk,Bruno M. Humbel,Ulrike Ziese,Janice Griffith,George Posthuma,Jan W. Slot,Abraham J. Koster,Arie J. Verkleij,Hans J. Geuze,Monique J. Kleijmeer +9 more
TL;DR: In this paper, it was shown that in multivesicular endosomes of B-lymphocytes and dendritic cells, the inner membranes are free vesicles and that protein transport from inner to outer membranes cannot occur laterally in the plane of the membrane, but requires fusion between the two membrane domains.
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PML in a Patient without Severe Lymphocytopenia Receiving Dimethyl Fumarate
TL;DR: Progressive multifocal leukoencephalopathy developed in a 64-year-old woman who was treated with compounded dimethyl fumarate for psoriasis andymphocytopenia in this patient was not as severe as in other patients with PML receiving fumaric acid esters.