M
Maarten B. Rookmaaker
Researcher at Utrecht University
Publications - 68
Citations - 2771
Maarten B. Rookmaaker is an academic researcher from Utrecht University. The author has contributed to research in topics: Medicine & Kidney disease. The author has an hindex of 18, co-authored 57 publications receiving 2156 citations. Previous affiliations of Maarten B. Rookmaaker include University Medical Center Utrecht.
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Journal ArticleDOI
Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes
Cindy J.M. Loomans,Eelco J.P. de Koning,Frank J. T. Staal,Maarten B. Rookmaaker,C. Verseyden,Hetty C. de Boer,Marianne C. Verhaar,Branko Braam,Ton J. Rabelink,Anton Jan van Zonneveld +9 more
TL;DR: It is demonstrated that adverse metabolic stress factors in type 1 diabetes are associated with reduced EPC numbers and angiogenicity, and hypothesize that EPC dysfunction contributes to the pathogenesis of vascular complications intype 1 diabetes.
Journal ArticleDOI
Tubuloids derived from human adult kidney and urine for personalized disease modeling
Frans Schutgens,Frans Schutgens,Maarten B. Rookmaaker,Thanasis Margaritis,Anne C. Rios,Carola Ammerlaan,Carola Ammerlaan,Jitske Jansen,Linda Gijzen,Marianne K. Vormann,Annelotte M. Vonk,Marco C. Viveen,Fjodor A. Yousef Yengej,Fjodor A. Yousef Yengej,Sepide Derakhshan,Karin M. de Winter-de Groot,Benedetta Artegiani,Ruben van Boxtel,Edwin Cuppen,Antoni P. A. Hendrickx,Marry M. van den Heuvel-Eibrink,Ellen Heitzer,Henriëtte L. Lanz,Jeffrey M. Beekman,Jean-Luc Murk,Rosalinde Masereeuw,Frank C. P. Holstege,Jarno Drost,Marianne C. Verhaar,Hans Clevers +29 more
TL;DR: Conditions for the long-term growth of primary kidney tubular epithelial organoids, or ‘tubuloids’, are described and tubuloids grown from human kidney tissue and urine aid the study of BK virus infection, Wilms tumors and cystic fibrosis.
Journal ArticleDOI
Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.
Nick Barker,Maarten B. Rookmaaker,Pekka Kujala,Annie Ng,Marc Leushacke,Hugo J. Snippert,Marc van de Wetering,Shawna Tan,Johan H. van Es,Meritxell Huch,Richard Poulsom,Richard Poulsom,Marianne C. Verhaar,Peter J. Peters,Hans Clevers +14 more
TL;DR: The Lgr5 surface marker and experimental models described here will be invaluable for deciphering the contribution of early nephron stem cells to developmental defects and for isolating human nephrons progenitors as a prerequisite to evaluating their therapeutic potential.
Journal ArticleDOI
Bone-marrow-derived cells contribute to glomerular endothelial repair in experimental glomerulonephritis
Maarten B. Rookmaaker,Anke M. Smits,Herman Tolboom,Karin Van 't Wout,Anton C.M. Martens,Roel Goldschmeding,Jaap A. Joles,Anton Jan van Zonneveld,Herman Joseph Gröne,Ton J. Rabelink,Marianne C. Verhaar +10 more
TL;DR: The data show that BM-derived cells participate in glomerular endothelial and mesangial cell turnover and contribute to microvascular repair and suggest a potential role for stem cell therapy.
Journal ArticleDOI
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
Camilla Calandrini,Frans Schutgens,Rurika Oka,Thanasis Margaritis,Tito Candelli,Luka Mathijsen,Carola Ammerlaan,Ravian L. van Ineveld,Sepide Derakhshan,Sanne de Haan,Emmy Dolman,Philip Lijnzaad,Lars Custers,Harry Begthel,Hindrik H. D. Kerstens,Lindy L. Visser,Maarten B. Rookmaaker,Marianne C. Verhaar,Godelieve A.M. Tytgat,Patrick Kemmeren,Ronald R. de Krijger,Reem Al-Saadi,Kathy Pritchard-Jones,Marcel Kool,Anne C. Rios,Marry M. van den Heuvel-Eibrink,Jan J. Molenaar,Ruben van Boxtel,Frank C. P. Holstege,Hans Clevers,Jarno Drost +30 more
TL;DR: The first paediatric cancer organoid biobank of tumour and matching normal kidney organoids from over 50 children with different subtypes of kidney cancer is described, providing a representative collection of well-characterised models for basic cancer research, drug-screening and personalised medicine.